E-Dissertationen: Suche
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Unravelling the role of RIM proteins in synaptic transmission: RIM1α tunes Ca2+ channel subtype contribution to neurotransmitter release
(2019-04-12)
Synaptic transmission is extremely fast and tightly regulated due to the rapid and spatially restricted Ca2+ signal at the presynaptic active zone (AZ). At the AZ, voltage-gated Ca2+ channels (VGCC) ...
Function and diversity of myeloid cells during chronic inflammation in non-lymphoid organs
(2020-03-10)
Different immune cells play a major role in maintaining tissue homeostasis, tissue repair but also in inflammation. Tissue integrity is mainly controlled by tissue regulatory T cells (Tregs), type 2 innate ...
Essential and complementary function of dendritic cell subsets during immunotherapy
(2020-03-11)
T lymphocytes are critical components of the adaptive immune system that protects us against a variety of infections. However, during chronic infections such as with HIV, HCV and HBV as well as cancers, T cells become ...
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
(2022-04-22)
Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ......
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Investigation of Heat Shock Protein 70 and Toll-like Receptor 4 functions during inflammation reaction by mechanical compression in human periodontal ligament cells
(2021-06-24)
Biomechanical forces exerted during treatment with orthodontic appliances cause tensile and compressive strain within the periodontal ligament (PDL) of affected teeth followed by ischemia on the compression side. Further, ...
Somatic cell-derived extracellular vesicles and phenotypic outcomes in the next generation
(2023-05-31)
Evidence from both human and animal studies demonstrate that paternal experiences and exposures can cause phenotypic changes in the next generation. Extracellular vesicles (EVs) released by somatic cells are hypothesised ...
Extracellular Vesicles in Hepatobiliary Cancer Management
(2023-04-19)
Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ...
CA1 Network Dynamics During Impaired Working Memory in Temporal Lobe Epileptic Mice
(2023-06-12)
Around 50 million people worldwide suffer from epilepsy. Seizures are not the only feature of epilepsy that patients suffer from. Despite the fact that other comorbidities of epilepsy such as memory deficits widely impact ...