Fakultäten der Universität Bonn: Suche
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PPARγ in myeloid cells controls CNS autoimmunity
(2012-03-12)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that regulates the immunogenicity of myeloid cells such as dendritic cells (DCs), macrophages, and ......
Microglia derived from embryonic stem cells and its application in CNS diseases
(2012-08-01)
Microglia are the resident immune cells of the central nervous system (CNS). They are known to have detrimental as well as beneficial effects. To overcome the limitations of primary microglia, embryonic stem cell derived ......
The role of PPARγ in myeloid cells in experimental autoimmune encephalomyelitis
(2013-05-06)
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the central nervous system (CNS) affecting more than 1 million people worldwide. It mainly affects young adults and has a great impact on ......
Multiple Sklerose ist eine weitverbreitete chronisch-entzündliche, demyelinisierende Erkrankung des Zentralen Nerven Systems (ZNS), an der weltweit mehr als 1 Millionen Menschen erkrankt sind. Sie betrifft überwiegend junge ......
Multiple Sklerose ist eine weitverbreitete chronisch-entzündliche, demyelinisierende Erkrankung des Zentralen Nerven Systems (ZNS), an der weltweit mehr als 1 Millionen Menschen erkrankt sind. Sie betrifft überwiegend junge ......
The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation
(2014-03-07)
Microglia are the resident immune cells of the central nervous system (CNS). They display a whole set of recognition receptors on their cell surface to sense intact or lesioned cells in the CNS. A subfamily of these receptors ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
The role of the endocannabinoid system in stress-related disorders and neuroimmune communication
(2020-05-04)
In the last decades, increasing evidence suggests that inflammatory processes play an important role in the development of psychiatric disorders, such as anxiety and depression. Psychosocial stress – one of the main ...
The role of endocannabinoid system in neuron-glial communication in the ageing and diseased brain
(2017-12-13)
The endocannabinoid system has been implicated in the regulation of glial activity and progression of brain ageing. Mice constitutively or specifically lacking the cannabinoid receptor 1 (CB1) on neurons or GABAergic neurons ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Molecular Mechanisms in the Unconventional Secretion of Insulin-Degrading Enzyme
(2018-04-12)
Extracellular deposition of amyloid-ß (Aß) plaques in the brain, a hallmark of Alzheimer’s disease (AD), results from an imbalance between production and clearance of the peptide. Insulin-degrading enzyme (IDE) is one of ...