Faculties of University Bonn: Search
Now showing items 1141-1150 of 1314
Nemertean Systematics: Usefulness of DNA Barcoding and DNA Taxonomy for Species Identification, Delimitation, and Population Analyses
(2022-04-21)
The assessment of phylogenetic relationships and systematics of all metazoan taxa heavily relies on the accurate identification and delimitation of species. For the past two centuries, both species identification and ...
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
(2022-04-22)
Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ......
Einfluss der zellspezifischen Deletion des miR-17~92-Clusters auf die Entwicklung des Kleinhirns
(2022-06-28)
Seit der Entdeckung der ersten micro-Ribonukleinsäure (miRNA/miR) wurde intensiv an der Funktion von miRNAs bei der Entwicklung des Kleinhirns geforscht. Dennoch sind die Mechanismen, über die miRNAs die beteiligten ...
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Mass Spectrometric Profiling of Lysosomal Protein Interactions, Structures, and Half-lives via Cross-Linking and Pulse Stable Isotope Labeling
(2022-07-08)
In mammalian cells, the lysosome is the central organelle for the degradation of macromolecules and recycling of their building blocks. Mutations in almost every known lysosomal hydrolase lead to a group of rare but ...
Neural Network Growth, Structure and Dynamics
(2022-07-13)
The evolutionary emergence of the nervous system provided individual organisms with a substrate for the development of complex behaviors and fast adaptations to dynamic environments. One of the main ways a nervous system ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Generation of an in vitro embryo model based on cellular reprogramming paradigms in embryonic stem cells
(2022-06-30)
This research project focuses on the generation and characterization of a stem cell-based organoid model system, that can model early murine embryonic development in vitro and ex utero. Such embryo-like cell culture models ......
Wax Ester Synthases/Acyl-CoA:Diacylglycerol Acyltransferases (WS/DGATs) from Arabidopsis thaliana
(2022-06-22)
Wax esters occur in the surface wax of plants and are involved amongst others in the plant’s response to drought. In Arabidopsis thaliana, a family of 11 genes are annotated as bifunctional wax ester synthases/acyl-CoA ......