Faculties of University Bonn: Search
Now showing items 71-80 of 160
Replicability and reliability of the background and target velocity effects in smooth pursuit eye movements
(2021-07-07)
When we follow a slowly moving target with our eyes, we perform smooth pursuit eye movements (SPEM). Previous investigations point to significantly and robustly reduced SPEM performance in the presence of a stationary ...
Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology
(2021-02-23)
Tissue-resident innate immune cells exert a wide range of functions in both adult
homeostasis and pathology. Our understanding of when and how these cellular
networks are established has dramatically changed with the ...
Assessing the quality of life of patients with metastatic castration-resistant prostate cancer with bone metastases receiving [223Ra]RaCl2 therapy
(2020-08-19)
[223Ra]RaCl2 dichloride treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) is associated with improved overall survival (OS) and a delay in the time to the first ...
Trucking with Time: The Emergence of New Mongolian Mobilities in America
(2021-06-08)
How do time, space, and movement interpenetrate to shape the life choices of Mongolian men living in Los Angeles? In this article I contribute to an ongoing scholarly debate about how Mongolian lives have been affected ...
Shedding light on the role of cAMP in mammalian sperm physiology
(2018-06-15)
Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
(2019-11-14)
The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...
How to control cyclic nucleotide signaling by light
(2017-03-10)
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ......
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
(2022-12-21)
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and ...
Glucocorticoids in relation to behavior, morphology, and physiology as proxy indicators for the assessment of animal welfare: A systematic mapping review
(2023-01-06)
Translating theoretical concepts of animal welfare into quantitative assessment protocols is an ongoing challenge. Glucocorticoids (GCs) are frequently used as physiological measure in welfare assessment. The interpretation ...
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
(2022-11-15)
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 ...