Search

Now showing items 1-2 of 2

Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides

Dreckmann, Teresa M.; Fritz, Lisa; Kaiser, Christian F.; Bouhired, Sarah M.; Wirtz, Daniel A.; Rausch, Marvin; Müller, Anna; Schneider, Tanja; König, Gabriele M.; Crüsemann, Max (2024-08-16)

Corallorazines are cyclic lipodipeptide natural products produced by the myxobacterium Corallococcus coralloides B035. To decipher the basis of corallorazine biosynthesis, the corallorazine nonribosomal peptide synthetase ......

Structure-affinity and structure-residence time relationships of macrocyclic Gα_q protein inhibitors

Voss, Jan H.; Crüsemann, Max; Bartling, Christian R.O.; Kehraus, Stefan; Inoue, Asuka; König, Gabriele M.; Strømgaard, Kristian; Müller, Christa E. (2023-04-21)

The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gα_q/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, ...