The navigation of precursor cells of inhibitory interneurons from their germinal zone inside the fourth ventricle through the white matter towards their final destination within the cerebellum's molecular layer is an ongoing ...

Cancer is a major burden of disease around the globe and one of the leading causes of premature death. The key to improve patient outcomes in modern clinical cancer research is to gain insights into dynamics underlying ...

The field of systems biology makes an attempt to realise various biological functions and processes as the emergent properties of the underlying biochemical network model. The area of computational systems biology deals ...

Mathematical models are in focus of modern systems biology and increasingly important to understand and manipulate complex biological systems. At the same time, new and improved techniques in metabolomics and proteomics ...

Oncolytic virus therapy (OVT) is emerging as a potent alternative to conventional cancer treatments by employing engineered viruses that selectively infect and lyse tumor cells while sparing normal tissues. Although ...

Organoids have rapidly matured into powerful model systems. The field is pushing organoids toward architectural sophistication and functional fidelity, with longitudinal experiments producing ever-larger and more complex ...

Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......

This thesis focuses on developing mathematical models utilizing complex biomedical datasets to understand epidemiological and cell-biological processes. The thesis is divided into three primary research articles and addresses ...

The estimation of unknown parameters is a key step in the development of mechanistic dynamical models for biological processes. While quantitative measurements are typically used for model calibration, in many applications, ...