Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Integrated structural biology investigation of the bacterial TRAP transporter SiaPQM from pathogenic bacteria
(2023-10-31)
Sialic acid is utilized by human pathogens like Vibrio cholerae in various ways to colonize the host. Upon contamination it scavenges the sialic acid from mucus-rich parts of the body such as the gut and causes the disease ......
Study of random Schrödinger operators away from the standard Anderson model: correlations and non-locality
(2023-10-31)
This thesis focuses on the investigation of two distinct variations of the Anderson model, where we relax the standard assumptions. In the first half of our study, we investigate a version of the Anderson model on the ...
Medicinal chemistry and molecular pharmacology of orphan human Mas-related G protein-coupled receptors X2 and X4 (MRGPRX2 and MRGPRX4)
(2021-10-19)
The MRGPRX protein subfamily comprise rhodopsin-like orphan GPCRs, whose endogenous agonists have not been identified yet. They are exclusively expressed in primates, including humans. All Mas-related GPCRs (MRGPRs) were ...
Design and Synthesis of A2B- and Dual-Acting A2A/A2B Adenosine Receptor Antagonists
(2020-10-27)
A2A and A2B adenosine receptors (ARs) are novel drug targets in cancer (immuno)therapy. Activation of A2AARs expressed on the surface of many immune cells such as T-lymphocytes and natural ...
In vitro aqueous alteration experiments on cortical bone: Quantification and visualization of alteration effects from the micro- down to the atomic scale
(2022-10-14)
This dissertation addresses the effects of early diagenetic processes on vertebrate bone's organic and inorganic constituents in an aquatic environment.
For this purpose, in vitro alteration experiments were ...
For this purpose, in vitro alteration experiments were ...
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Investigating Graph Representation Learning Methods For Link Prediction in Knowledge Graphs
(2023-11-03)
Knowledge Graphs (KGs) have become a fundamental approach to represent structured data and are employed in academic and industrial applications.
KGs are used in various machine learning applications, such as question ...
Implementation of a high throughput screening assay to identify and characterize insecticides acting on ion channels
(2023-11-03)
With 800 million people suffering from hunger, new innovative crop protection products are required to ensure food supply and stop hunger.
The voltage-sensitive sodium channel (VSSC) was shown to be a safe and effective ...
Assimilation of 3D Polarimetric Microphysical Retrievals with an Ensemble Kalman Filter in Germany
(2023-11-06)
Accurate quantitative precipitation forecasts (QPF) by numerical weather prediction (NWP) models are and remain of high societal interest, especially in times of global warming, which causes an increasing frequency and ...
New Insights into Terpene Synthase Catalysis for Rational Enzyme Engineering
(2023-11-07)
This doctoral dissertation consists of 4 reviews and 16 research articles that present mechanistic studies on terpene biosynthesis. Specifically, sesquiterpenes biosynthetically derived from germacrene A, hedycaryol and ...
