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A stochastic modelling framework for cancer patient trajectories: combining tumour growth, metastasis, and survival 

Wieland, Vincent; Hasenauer, Jan (2025-05-22)
Cancer is a major burden of disease around the globe and one of the leading causes of premature death. The key to improve patient outcomes in modern clinical cancer research is to gain insights into dynamics underlying ...
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Next-generation discovery: empowering organoid research with machine learning, artificial intelligence, and mathematical modeling 

Pushpa Ramesan, Sneha; Boovadira Poonacha, Jasmitha; Pathirana, Dilan; Merkt, Simon; Maass, Christian; Hasenauer, Jan; Reckzeh, Elena S. (2026-03-13)
Organoids have rapidly matured into powerful model systems. The field is pushing organoids toward architectural sophistication and functional fidelity, with longitudinal experiments producing ever-larger and more complex ...
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Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy 

Pinedo-Diaz, German; Lorenz, Birgit; Künzel, Sandrine H.; Thiele, Sarah; Ortega-Cisneros, Susana; Bayro Corrochano, Eduardo; Holz, Frank G.; Effland, Alexander (2025-01-02)
PURPOSE. To quantify outer retina structural changes and define novel biomarkers of inherited retinal degeneration associated with biallelic mutations in RPE65 (RPE65-IRD) in patients before and after ......

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AuthorHasenauer, Jan (2)Bayro Corrochano, Eduardo (1)Boovadira Poonacha, Jasmitha (1)Effland, Alexander (1)Holz, Frank G. (1)Künzel, Sandrine H. (1)Lorenz, Birgit (1)Maass, Christian (1)Merkt, Simon (1)Ortega-Cisneros, Susana (1)... View MoreSubjectartificial intelligence (1)Cancer modelling (1)deep learning–based image segmentation (1)ellipsoid zone biomarkers (1)gene augmentation therapy (1)machine learning (1)mathematical modeling (1)Mathematical oncology (1)organoids (1)RPE65-IRD (1)... View MoreClassification (DDC)
510 Mathematik (3)
610 Medizin, Gesundheit (3)
570 Biowissenschaften, Biologie (2)004 Informatik (1)500 Naturwissenschaften (1)... View MoreResource Type
Wissenschaftlicher Artikel (3)
... View MoreDate Issued2025 (2)2026 (1)Open Access Fund (University of Bonn)OA-Förderung Universität Bonn (1)... View More

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