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Complete genome sequence of Pediococcus pentosaceus 13.7 2A-1 isolated from a Holstein Friesian dairy cattle
(2025-10-02)<em>Pediococcus pentosaceus</em> was isolated from a Holstein Friesian dairy cattle from a conventionally operated farm. The complete genome of strain <em>P. pentosaceus</em> 13.7 2A-1 comprises 1.84 Mbp and 1,746 ... -
Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research
(2025-06-30)Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chemical inducers, light-dependent control of gene expression by optogenetics ... -
Strong Association of Perceived Chronic Stress with Leadership Quality, Work–Privacy Conflict and Quantitative Work Demands: Results of the IMPROVEjob Study
(2025-05-03)The health of primary care professionals is crucial for the health of populations. A lower number of general practitioners per 1000 patients correlates with higher patient mortality. Challenging work demands, work–privacy ... -
FVIII Trafficking Dynamics Across Subcellular Organelles Using CRISPR/Cas9 Specific Gene Knockouts
(2025-07-01)Factor VIII (FVIII) interacts with Endoplasmic Reticulum (ER) chaperones Calnexin (CANX) and Calreticulin (CALR) and with ER-Golgi Intermediate Compartment (ERGIC) transporters, Lectin, mannose-binding 1 (LMAN1) and Multiple ... -
Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease
(2025-08-26)Autosomal-dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized bymutations in <em>PKD1</em> or <em>PKD2</em>, which drive cystogenesis in renal epithelial cells. Immune cells, particularly macrophages, ... -
A multi-group path analysis of medication documentation quality using cross-sectional survey data: Impact of leadership, job satisfaction, patient-related burnout, and patient safety culture
(2025-09-12)Medication-related adverse events are a major problem for patient safety and quality of care. This study explored the effects of leadership, job satisfaction, patient-related burnout and patient safety culture, measured ... -
Short physical performance battery: Pilot study of a human motion capture app (MobiSPPB)
(2025-07-02)<strong>Background:</strong> A standardized fall risk assessment can guide targeted interventions. The widely used short physical performance battery (SPPB) for mobility assessment covers balance, gait speed, and lower ... -
Case Report: Practical approach to unmask unspecific adverse effects under lipid-lowering medication
(2025-05-27)The nocebo effect, driven by negative expectations rather than pharmacological mechanisms, contributes significantly to medication non-adherence, particularly in lipid-lowering therapy. Up to 50% of reported statin-related ... -
Primary cilia signalling at a glance
(2025-10-29)The primary cilium is a solitary, microtubule-based organelle present on most vertebrate cells, where it functions as a central hub for sensing and transducing extracellular signals. This Cell Science at a Glance article ... -
Potential of Aframomum melegueta and Xylopia aethiopica Against Taenia spp.: Plant-Based Remedies as Novel Anthelmintics
(2025-05-19)<strong>Background/Objectives: </strong>Taeniasis, a zoonotic infection, is a common foodborne disease. Niclosamide and praziquantel have proven to be effective in treating it, but the use of the same drugs can lead to ... -
Sialylation as a checkpoint for inflammatory and complement-related retinal diseases
(2025-06-27)Sialylation is a modification process involving the addition of sialic acid residues to the termini of glycoproteins and glycolipids in mammalian cells. Sialylation serves as a crucial checkpoint inhibitor of the complement ... -
Drinking Water and Sanitation Safety Planning for Medical Facilities: An Innovative PoU Approach for a Water System Description Using Ecomaps
(2025-06-26)Drinking Water Safety Plans (DWSP) in buildings serve to identify health hazards associated with the drinking water system. Sanitation Safety Plans (SSP) fulfill the same purpose for the sewage system. Water Safety Plans ... -
Alterations in dopaminergic innervation and receptors in focal cortical dysplasia
(2025-04-16)Focal cortical dysplasia (FCD) type 2 is the most common malformation of cortical development associated with pharmaco-resistant focal epilepsy and frequently located in the frontal cortex. Neuropathological hallmarks ... -
Quality Management Outweighs Pandemic: Retrospective Analysis Shows Improved Quality of Care for Staphylococcus aureus Bacteremia Despite SARS-CoV-2
(2025-03-30)Background: <em>Staphylococcus aureus</em> bacteremia (SAB) is of great clinical relevance, as it is the most common type of bacteremia. Several studies show that the quality of care and thus the outcome can be positively ... -
Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana
(2025-03-13)Background/Objectives: Although the COVID-19 pandemic has largely concluded, the varied trajectories it has followed in different regions of the world remain incompletely understood. Intensive research is needed to fully ... -
Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation
(2025-02-28)Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance (<em>R<sub>m</sub></em>), pacing threshold (<em>I<sub>thr</sub></em>), and cardiac space ... -
Psychological safety, job satisfaction, and the intention to leave among German early-career physicians
(2025-01-17)<strong>Background</strong> Healthcare systems worldwide experience shortages of healthcare professionals. Retention of physicians is becoming an increasing problem. The psychological safety among physicians affects not ... -
Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators
(2024-07-23)Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression ... -
Use of the FallAkte Plus System as an IT Infrastructure for the North Rhine-Westphalian General Practice Research Network: Mixed Methods Usability Study
(2024-05-20)<strong>Background:</strong> Primary care research networks can generate important information in the setting where most patients are seen and treated. However, this requires a suitable IT infrastructure (ITI), which the ...
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