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  • Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators 

    Masala, Nicola; Mittag, Manuel; Ambrad Giovannetti, Eleonora; O'Neil, Darik A.; Distler, Fabian J.; Rupprecht, Peter; Helmchen, Fritjof; Yuste, Rafael; Fuhrmann, Martin; Beck, Heinz; Wenzel, Michael; Kelly, Tony (2024-07-23)
    Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression ...

  • Use of the FallAkte Plus System as an IT Infrastructure for the North Rhine-Westphalian General Practice Research Network: Mixed Methods Usability Study 

    Bozorgmehr, Arezoo; Thiem, Simon-Konstantin; Wild, Dorothea; Reinsdorff, Melanie; Vollmar, Horst Christian; Kappernagel, Annika; Schloessler, Kathrin; Weissbach, Sabine; Pentzek, Michael; Dehnen, Dorothea; Drexler, Julia; Mueller, Beate Sigrid; Pilic, Larisa; Lehmann, Lion; Loescher, Susanne; Hohmann, Elena Darinka; Frank, Friederike; Ates, Gülay; Kersten, Susanne; Mortsiefer, Achim; Aretz, Benjamin; Weltermann, Birgitta (2024-05-20)
    <strong>Background:</strong> Primary care research networks can generate important information in the setting where most patients are seen and treated. However, this requires a suitable IT infrastructure (ITI), which the ...

  • Assessing Electronic Health Literacy in Individuals With the Post–COVID-19 Condition Using the German Revised eHealth Literacy Scale: Validation Study 

    Marsall, Matthias; Dinse, Hannah; Schröder, Julia; Skoda, Eva-Maria; Teufel, Martin; Bäuerle, Alexander (2024-04-25)
    <strong>Background:</strong> The eHealth Literacy Scale (eHEALS) is a widely used instrument for measuring eHealth literacy (eHL). However, little is known so far about whether the instrument is valid for the assessment ...

  • Prospective effects of an artificial intelligence-based computer-aided detection system for prostate imaging on routine workflow and radiologists' outcomes 

    Wenderott, Katharina; Krups, Jim; Luetkens, Julian A.; Gambashidze, Nikoloz; Weigl, Matthias (2023-12-06)
    <em>Objectives:</em> Artificial intelligence (AI) is expected to alleviate the negative consequences of rising case numbers for radiologists. Currently, systematic evaluations of the impact of AI solutions in real-world ...

  • Development of the "Scale for the assessment of non-experts' AI literacy": an exploratory factor analysis 

    Laupichler, Matthias Carl; Aster, Alexandra; Haverkamp, Nicolas; Raupach, Tobias (2023-09-27)
    Artificial Intelligence competencies will become increasingly important in the near future. Therefore, it is essential that the AI literacy of individuals can be assessed in a valid and reliable way. This study presents ...

  • 33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52 

    Dehnen, Dorothea; Reinsdorff, Melanie; Weltermann, Birgitta (2024-07-11)
    <strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ...

  • Mouse models of type I interferonopathies 

    Luca, Domnica; Kato, Hiroki (2024-12-16)
    Type I interferonopathies are severe monogenic diseases caused by mutations that result in chronically upregulated production of type I interferon. They present with a broad variety of symptoms, the mechanisms of which are ...

  • Epidemiology and outcomes of vancomycin-resistant enterococcus infections: A systematic review and meta-analysis 

    Eichel, Vanessa M.; Last, Katharina; Brühwasser, Christina; Baum, Heike von; Dettenkofer, Markus; Götting, Tim; Grundmann, Hajo; Güldenhöven, Hanna; Liese, Jan; Martin, Maria; Papan, Cihan; Sadaghiani, Catharina; Wendt, Constanze; Werner, Guido; Mutters, Nico (2023-09-19)
    Vancomycin-resistant enterococci (VRE) cause many infections in the healthcare context. Knowledge regarding the epidemiology and burden of VRE infections, however, remains fragmented. We aimed to summarize recent studies ...

  • Evaluating AI Courses: A Valid and Reliable Instrument for Assessing Artificial-Intelligence Learning through Comparative Self-Assessment 

    Laupichler, Matthias Carl; Aster, Alexandra; Perschewski, Jan-Ole; Schleiss, Johannes (2023-09-26)
    A growing number of courses seek to increase the basic artificial-intelligence skills ("AI literacy") of their participants. At this time, there is no valid and reliable measurement tool that can be used to assess AI-learning ...

  • Key factors for sustainable working conditions in emergency departments: An EUSEM-initiated, Europe-wide consensus survey 

    Weigl, Matthias; Lifschitz, Michael; Dodt, Christoph (2025-02)
    <em>Background and importance</em> Modern emergency medicine (EM) is a complex, demanding, and occasionally stressful field of work. Working conditions, provider well-being, and associated health and performance outcomes ...

  • Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function 

    Khani, Sajjad; Topel, Hande; Kardinal, Ronja; Tavanez, Ana Rita; Josephrajan, Ajeetha; Larsen, Bjørk Ditlev Marcher; Gaudry, Michael James; Leyendecker, Philipp; Meincke Egedal, Nadia; Güller, Aylin Seren; Stanic, Natasa; Ruppert, Phillip M. M.; Gaziano, Isabella; Hansmeier, Nils Rouven; Schmidt, Elena; Klemm, Paul; Vagliano, Lara-Marie; Stahl, Rainer; Duthie, Fraser; Krause, Jens-Henning; Bici, Ana; Engelhard, Christoph Andreas; Gohlke, Sabrina; Frommolt, Peter; Gnad, Thorsten; Rada-Iglesias, Alvaro; Pradas-Juni, Marta; Schulz, Tim Julius; Wunderlich, Frank Thomas; Pfeifer, Alexander; Bartelt, Alexander; Jastroch, Martin; Wachten, Dagmar; Kornfeld, Jan-Wilhelm (2024-04-29)
    Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ...

  • TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies 

    Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A.; Tan, Wen-Hann; Coury, Stephanie A.; Woerner, Audrey C.; Sebastian, Jessica; Levy, Paul A.; Fleming, Leah R.; Waffenschmidt, Lea; Lindenberg, Tobias T.; Yilmaz, Öznur; Channab, Khadija; Babra, Bimaljeet K.; Christ, Andrea; Eiberger, Britta; Hölzel, Selina; Vidic, Clara; Häberlein, Felix; Ishorst, Nina; Rodriguez-Gatica, Juan E.; Pezeshkpoor, Behnaz; Kupczyk, Patrick A.; Vanakker, Olivier M.; Loddo, Sara; Novelli, Antonio; Dentici, Maria L.; Becker, Albert; Thiele, Holger; Posey, Jennifer E.; Lupski, James R.; Hilger, Alina C.; Reutter, Heiko M.; Merz, Waltraut M.; Dworschak, Gabriel C.; Odermatt, Benjamin (2024-12-23)
    <strong>Background</strong> Previous studies in mouse, <em>Xenopus</em> and zebrafish embryos show strong <em>tfap2e</em> expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in ...

  • NIS-Seq enables cell-type-agnostic optical perturbation screening 

    Fandrey, Caroline I.; Jentzsch, Marius; Konopka, Peter; Hoch, Alexander; Blumenstock, Katja; Zackria, Afraa; Maasewerd, Salie; Lovotti, Marta; Lapp, Dorothee J.; Gohr, Florian N.; Suwara, Piotr; Świeżewski, Jędrzej; Rossnagel, Lukas; Gobs, Fabienne; Cristodaro, Maia; Muhandes, Lina; Behrendt, Rayk; Lam, Martin C.; Walgenbach, Klaus J.; Bald, Tobias; Schmidt, Florian I.; Latz, Eicke; Schmid-Burg, Jonathan L. (2024-12-19)
    Optical pooled screening offers a broader-scale alternative to enrichment-based perturbation screening, using fluorescence microscopy to correlate phenotypes and perturbations across single cells. Previous methods work ...

  • Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei 

    Kien, Chi Anizette; Ebai, Rene; Fombad, Fanny Fri; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Chunda, Valerine Chawa; Ekanya, Relindis; Nietcho, Franck Noel; Foyet, Juluis Visnel; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-12-10)
    <strong>Background:</strong> <em>Mansonella perstans</em> is transmitted by <em>Culicoides</em> species and affects hundred millions of inhabitants in about 33 countries in sub-Saharan Africa. It is known that Mansonellosis ...

  • Schistosomiasis–Microbiota Interactions: A Systematic Review and Meta-Analysis 

    Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Kyei, Samuel; Arndts, Kathrin; Ritter, Manuel; Asare, Kwame Kumi (2024-10-16)
    Introduction: Schistosomiasis, a tropical disease affecting humans and animals, affected 251.4 million people in 2021. <em>Schistosoma mansoni, S. haematobium, S. intercalatum</em>, and <em>S. japonicum</em> are primary ...

  • Barriers and Facilitators of Patient Engagement Activities to Improve Patient Safety in Healthcare Organizations: A Delphi-Based Expert Survey 

    Koch, Amelie; Brust, Larissa; Weigl, Matthias (2024-12-19)
    <strong>Purpose:</strong> In order to obtain sustainable healthcare, engagement of patients in patient safety improvement is vital. Drawing upon a multi-perspective approach, this study aimed to investigate perspectives ...

  • Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon 

    Magha, Chefor; Nchang, Lucy Cho; Weldeslassie, Michael; Nkimbeng, Desmond Akumtoh; Tchatat, Nancielle Mbiatong; Meriki, Henry Dilonga; Deribe, Kebede; Nietcho, Frank Noel; Foyet, Juluis Visnel; Fombad, Fanny Fri; Katcho, Tatiana Djikeussi; Fru Cho, Jerome; Gebremeskel, Eyoab Iyasu; Waddell, Simon J.; Bobosha, Kidist; Newport, Melanie J.; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-10-02)
    <strong>Introduction:</strong> Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) treatment management ...

  • Innovative Regional Services and Heterogeneous Communication Channels: Results from the Nationwide German egePan Project for Pandemic Management 

    Kugai, Simon; Aretz, Benjamin; Krumpholtz, Yelda; Schmidt, Manuela; Süssle, Daniela; Steyer, Linda; Henkel, Adrienne; Bender, Katrin; Girrbach, Felix; Stehr, Sebastian; Balzer, Katrin; Weltermann, Birgitta (2024-11-04)
    <strong>Background:</strong> In the COVID-19 pandemic, novel regional services and communication channels emerged across all sectors of the German healthcare system. To contribute to pandemic preparedness, this study aims ...

  • Schistosomiasis endemicity and its role in sexually transmitted infections: A systematic review and meta-analysis 

    Asare, Kwame Kumi; Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Arndts, Kathrin; Ritter, Manuel (2024-09-02)
    <strong>Introduction:</strong> Schistosomiasis, a tropical parasitic disease, affects 779 million people globally, with 85% of cases in Africa. The interplay between schistosomiasis and other sexually transmitted infections ...

  • In vitro extracellular replication of Wolbachia endobacteria 

    Behrmann, Lara Vanessa; Meier, Kirstin; Vollmer, Jennifer; Chiedu, Chukwuebuka Chibuzo; Schiefer, Andrea; Hoerauf, Achim; Pfarr, Kenneth (2024-07-18)
    Obligate intracellular endobacteria of the genus <em>Wolbachia</em> are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy ...

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