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The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex
(2024-07-05)The prefrontal cortex (PFC) undergoes a protracted maturation process. This is true both for local interneurons and for innervation from midbrain dopaminergic (mDA) neurons. In the striatum, dopaminergic (DA) neurotransmission ... -
Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains
(2024-04-15)<strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ... -
The unusual mode of action of the polyketide glycoside antibiotic cervimycin C
(2024-05-09)Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by <em>Streptomyces tendae</em> HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a ... -
The role of dendritic cells in MASH: friends or foes?
(2024-04-08)Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. ... -
Personal protective behaviors in response to COVID-19: a longitudinal application of protection motivation theory
(2023-08-15)<strong>Introduction:</strong> Disease outbreaks are expected to occur more frequently and spread more rapidly in the age of globalization. Personal protective behaviors strongly affect infection and death rates worldwide. ... -
Arterial Blood Supply of the Stifle Joint in Horses
(2024-04-24)The vascularization pattern of the equine stifle joint is insufficiently described in the literature, even though there is a growing need for knowledge of the exact blood supply, as (i) arthroscopy and endoscopic surgery ... -
NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer
(2024-04-24)<strong>PURPOSE</strong> The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet ... -
Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
(2024-02-13)<strong>Background:</strong> The world health organization (WHO) introduced the mass drug administration (MDA) strategy in order to reduce the prevalence of soil-transmitted helminths (STHs) and <em>Schistosoma mansoni</em> ... -
Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation
(2024-02-15)Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic ... -
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
(2024-02-19)<strong>Introduction:</strong> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver ... -
Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel: A Prospective Study
(2024-02-16)Background: The mental burdens of general practitioners (GPs) and practice assistants (PrAs) during the COVID-19 pandemic are well investigated. Work-related conditions like overtime are known to contribute to perceived ... -
Acceptability of surgical care in Uganda: a qualitative study on users and providers
(2023-07-31)<strong>Objectives</strong> This study was conducted to assess acceptability of surgical care in Eastern Uganda and enable better allocation of resources, and to guide health policy towards increased surgical care seeking.<br ... -
German GPs’ Self-Perceived Role in the COVID-19 Pandemic: Leadership, Participation in Regional Services and Preferences for Future Pandemic Preparedness
(2023-06-09)General practitioners (GPs) played a vital role during the COVID-19 pandemic. Little is known about GPs’ view of their role, leadership, participation in regional services and preferences for future pandemic preparedness. ... -
Measuring transitional patient safety: Adaptation and validation of the German version of the Care Transitions Measure = Messung der Patientensicherheit im Entlassungsprozess: Adaptation und Validierung der deutschen Version des Care Transitions Measure
(2023-12)<strong>Introduction:</strong> The transition between different care contexts, especially during discharge from inpatient treatment to home, is associated with risks for patient safety. Internationally established, the ... -
Silent Triage: Public Health decision-making beyond prioritisation
(2023-02-22)The COVID-19 pandemic has influenced clinical care and health service provision in low-income and middle-income countries. Besides having no timely access to routine vaccination, services for non-SARS-CoV-2-related health ... -
The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease
(2024-08-21)Prokaryotic CRISPR-Cas immune systems detect and cleave foreign nucleic acids. In type III CRISPR-Cas systems, the Cas10 subunit of the activated recognition complex synthesizes cyclic oligoadenylates (cOAs), second ... -
The missense mutation C667F in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
(2024-06-18)Dystroglycan (DG) is an extracellular matrix receptor consisting of an α- and a β-DG subunit encoded by the DAG1 gene. The homozygous mutation (c.2006G>T, p.Cys669Phe) in β-DG causes muscle-eye-brain disease with multicystic ... -
Neuropilin2 in Mesenchymal Stromal Cells as a Potential Novel Therapeutic Target in Myelofibrosis
(2024-05-18)Bone marrow fibrosis in myeloproliferative neoplasm (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap syndromes and acute myeloid leukemia (AML) is associated with poor prognosis and early treatment failure. Myelofibrosis ... -
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury
(2023-03-02)<strong>Background & Aims:</strong> Patients with chronic liver disease (CLD), including cirrhosis, are at increased risk of intractable viral infections and are hyporesponsive to vaccination. Hallmarks of CLD and cirrhosis ...
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