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Arterial Blood Supply of the Stifle Joint in Horses
(2024-04-24)The vascularization pattern of the equine stifle joint is insufficiently described in the literature, even though there is a growing need for knowledge of the exact blood supply, as (i) arthroscopy and endoscopic surgery ... -
NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer
(2024-04-24)<strong>PURPOSE</strong> The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet ... -
Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
(2024-02-13)<strong>Background:</strong> The world health organization (WHO) introduced the mass drug administration (MDA) strategy in order to reduce the prevalence of soil-transmitted helminths (STHs) and <em>Schistosoma mansoni</em> ... -
Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation
(2024-02-15)Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic ... -
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
(2024-02-19)<strong>Introduction:</strong> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver ... -
Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel: A Prospective Study
(2024-02-16)Background: The mental burdens of general practitioners (GPs) and practice assistants (PrAs) during the COVID-19 pandemic are well investigated. Work-related conditions like overtime are known to contribute to perceived ... -
Acceptability of surgical care in Uganda: a qualitative study on users and providers
(2023-07-31)<strong>Objectives</strong> This study was conducted to assess acceptability of surgical care in Eastern Uganda and enable better allocation of resources, and to guide health policy towards increased surgical care seeking.<br ... -
German GPs’ Self-Perceived Role in the COVID-19 Pandemic: Leadership, Participation in Regional Services and Preferences for Future Pandemic Preparedness
(2023-06-09)General practitioners (GPs) played a vital role during the COVID-19 pandemic. Little is known about GPs’ view of their role, leadership, participation in regional services and preferences for future pandemic preparedness. ... -
Measuring transitional patient safety: Adaptation and validation of the German version of the Care Transitions Measure = Messung der Patientensicherheit im Entlassungsprozess: Adaptation und Validierung der deutschen Version des Care Transitions Measure
(2023-12)<strong>Introduction:</strong> The transition between different care contexts, especially during discharge from inpatient treatment to home, is associated with risks for patient safety. Internationally established, the ... -
Silent Triage: Public Health decision-making beyond prioritisation
(2023-02-22)The COVID-19 pandemic has influenced clinical care and health service provision in low-income and middle-income countries. Besides having no timely access to routine vaccination, services for non-SARS-CoV-2-related health ... -
The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease
(2024-08-21)Prokaryotic CRISPR-Cas immune systems detect and cleave foreign nucleic acids. In type III CRISPR-Cas systems, the Cas10 subunit of the activated recognition complex synthesizes cyclic oligoadenylates (cOAs), second ... -
The missense mutation C667F in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
(2024-06-18)Dystroglycan (DG) is an extracellular matrix receptor consisting of an α- and a β-DG subunit encoded by the DAG1 gene. The homozygous mutation (c.2006G>T, p.Cys669Phe) in β-DG causes muscle-eye-brain disease with multicystic ... -
Neuropilin2 in Mesenchymal Stromal Cells as a Potential Novel Therapeutic Target in Myelofibrosis
(2024-05-18)Bone marrow fibrosis in myeloproliferative neoplasm (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap syndromes and acute myeloid leukemia (AML) is associated with poor prognosis and early treatment failure. Myelofibrosis ... -
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury
(2023-03-02)<strong>Background & Aims:</strong> Patients with chronic liver disease (CLD), including cirrhosis, are at increased risk of intractable viral infections and are hyporesponsive to vaccination. Hallmarks of CLD and cirrhosis ... -
Prediction of Chronic Stress and Protective Factors in Adults: Development of an Interpretable Prediction Model Based on XGBoost and SHAP Using National Cross-sectional DEGS1 Data
(2023-05-16)Background: Chronic stress is highly prevalent in the German population. It has known adverse effects on mental health, such as burnout and depression. Known long-term effects of chronic stress are cardiovascular disease, ... -
Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue
(2023-08-29)Macrophages are one of the prominent leukocyte populations in white adipose tissue (WAT) and play an important role during WAT homeostasis and remodeling. Macrophage function in WAT is determined by ontogeny and the local ... -
Enemy or ally? Fasting as an essential regulator of immune responses
(2021-04-14)Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are emerging as a central aspect of ... -
Innate lymphoid cells - key immune integrators of overall body homeostasis: ILC – key immune integrators of overall body homeostasis
(2018-06-04)The maintenance of the tissue barrier is essential to protect the host from external pathogens, thus ensuring the survival of the organism. This process requires the integration of various physiological signals originating ... -
Primary cilia and their effects on immune cell functions and metabolism: a model
(2022-05)Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ...
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