Medizinische Klinik und Poliklinik III - Innere Medizin

 

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  • Phytochemical combinations of lichen Evernia prunastri (L.) Ach. reduce drug resistance to temozolomide but not to paclitaxel in vitro 

    Shcherbakova, A.; Nguyen, L.; Koptina, A.; Backlund, A.; Banerjee, S.; Romanov, E.; Ulrich-Merzenich, G. (2025-09-15)
    <strong>Introduction:</strong> Temozolomide (TMZ) and Paclitaxel (PXT), crucial anti-cancer drugs for glioblastoma (GBM) and primary breast cancer (BC), respectively, face drug resistance. Therefore, we investigated the ...

  • Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres 

    Stefan, A. Juranek; Katrin, Paeschke (2012-05-01)
    DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed ...

  • Detecting G4 unwinding 

    Stefan, Juranek; Katrin, Paeschke (2022-04-18)
    DNA can, in addition to the B-DNA conformation, fold into a variety of additional conformations. Among them are G-quadruplex structures that have gained a lot of attention in recent years. G-quadruplex structures (G4s) are ...

  • The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes 

    Schult, Philipp; Paeschke, Katrin (2020-10-12)
    <em>DHX36</em> is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was ...