bonndoc - Der Publikationsserver der Universität Bonn: Neuzugänge
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Molecular tools, drugs and conjugates for the modulation of purinergic signal transduction
(2026-05-13)(noch nicht zugänglich / not yet accessible) -
Characterization of Toll-Like Receptor 8 and Its Modulation through Novel Small-Molecule Antagonists
(2026-05-13)Toll-like receptor 8 (TLR8) represents a key endosomal pattern recognition receptor that senses RNA degradation products to initiate proinflammatory signaling in myeloid cells, linking innate immunity to adaptive responses. ... -
Sonographische Sarkopeniediagnostik bei Patienten mit fortgeschrittener Lebererkrankung: Prädiktiver Wert für akute Dekompensationen und Mortalität
(2026-05-13)Sarkopenie stellt bei Patienten mit Leberzirrhose einen wichtigen Risikofaktor für Komplikationen und Mortalität dar. Etablierte diagnostische Verfahren sind jedoch häufig kostenintensiv, strahlenbelastend oder nur ... -
Intestinal Helminth Infection Modulates the Immune Response to Airway Allergens
(2026-05-13)Chronic diseases such as asthma have increased dramatically over the last century, coinciding with a decline in parasitic helminth infections. Allergic asthma is characterised by the expansion of type 2 immune cells, ... -
Supramolekulare Organisation auf Oberflächen und π-konjugierte Oligomere als funktionale Bausteine
(2026-05-13)Im Rahmen dieser Dissertation wurden Strategien zur gezielten Herstellung und Kontrolle supramolekularer Nanostrukturen auf Oberflächen im Kontext der organischen und supramolekularen Chemie untersucht. Ziel der Arbeit war ... -
Verträglichkeit und Wirksamkeit akzelerierter und zielgerichteter strahlentherapeutischer Behandlungskonzepte in der Neuroonkologie
(2026-05-12)Die Strahlentherapie ist eine zentrale Säule der Behandlung sowohl des Glioblastoms (GBM) als auch von Hirnmetastasen. Insbesondere für das GBM mangelt es jedoch weiterhin an dringend benötigten sinnvollen systemtherapeutischen ... -
Tracing the effects of stellar feedback on molecular gas from simulations to observations
(2026-05-12)The interstellar medium (ISM) is a turbulent, multi-phase medium with a hierarchical structure consisting of molecular clouds (MCs), clumps, and cores. Stars form in dense cores and, over their evolution, inject mass, ... -
A stochastic modelling framework for cancer patient trajectories: combining tumour growth, metastasis, and survival
(2025-05-22)Cancer is a major burden of disease around the globe and one of the leading causes of premature death. The key to improve patient outcomes in modern clinical cancer research is to gain insights into dynamics underlying ... -
Assessment of uncertainty quantification in universal differential equations
(2025-04-02)Scientific machine learning is a new class of approaches that integrate physical knowledge and mechanistic models with data-driven techniques to uncover the governing equations of complex processes. Among the available ... -
Next-generation discovery: empowering organoid research with machine learning, artificial intelligence, and mathematical modeling
(2026-03-13)Organoids have rapidly matured into powerful model systems. The field is pushing organoids toward architectural sophistication and functional fidelity, with longitudinal experiments producing ever-larger and more complex ... -
Parameter estimation and model selection for the quantitative analysis of oncolytic virus therapy in zebrafish
(2025-08-13)Oncolytic virus therapy (OVT) is emerging as a potent alternative to conventional cancer treatments by employing engineered viruses that selectively infect and lyse tumor cells while sparing normal tissues. Although ... -
Simulation-based inference of cell migration dynamics in complex spatial environments
(2026-01-29)To assess cell migration in complex spatial environments, microfabricated chips, such as mazes and pillar forests, are routinely used to impose spatial and mechanical constraints, and cell trajectories are followed within ... -
Identifiability and uncertainty for ordinary differential equation models with qualitative or semiquantitative data
(2025-09-26)The estimation of unknown parameters is a key step in the development of mechanistic dynamical models for biological processes. While quantitative measurements are typically used for model calibration, in many applications, ... -
The role of the NLRP3 inflammasome in neuroinflammation after neonatal hypoxic-ischemic brain injury
(2026-05-11)Worldwide, neonates are suffering from hypoxic-ischemic encephalopathy. The pathology can lead to neurological impairments and neonatal death and has an incidence of 1-3/1000 neonates in developed countries and 10-20 times ... -
Essays on Human Capital
(2026-05-11)This thesis comprises three essays that examine how human capital shapes economic outcomes across three distinct dimensions: as a motive for individual choices, as a determinant of industry composition, and as a measure ... -
Cycle Packing and Cycle Transversal in Graphs on Oriented Surfaces
(2026-05-11)The topics of this thesis are the Cycle Packing Problem and the Cycle Transversal Problem in planar or bounded-genus graphs. Given a graph <em>G</em> and an implicitly given family <em>C</em> of cycles in <em>G</em>, the ... -
Deep Learning for Predicting Impacts of Extreme Events and their Drivers
(2026-05-11)Climate change will apparently alter the patterns and frequencies of extreme weather and climate events. Yet, we still struggle to accurately localize and predict where extreme events and their impacts could occur in the ... -
Sampling-ADC based Pile-Up Recovery and Digital Signal Processing in the CBELSA/TAPS-Experiment
(2026-05-11)The CBELSA/TAPS experiment in Bonn investigates the spectrum and properties of baryon resonances by performing photoproduction experiments off the nucleon to reach a better understanding of quantum chromodynamics in the ... -
Essays in Behavioral and Experimental Economics
(2026-05-11)This dissertation examines how informational framing, cognitive complexity, and political identity shape beliefs and subsequent behavior. Across four chapters based on experimental studies, it investigates fairness judgments ... -
Real-world-Daten zu BRCA1/2- und HRR-Mutationen bei Patienten mit Prostatakarzinom
(2026-05-11)In der vorliegenden Arbeit wurde mit dem Ziel der Generierung von Real-world-Daten die Prävalenz von BRCA1/2- und HRR-Mutationen im Prostatakarzinom durch eine retrospektive Auswertung von 197 Fällen am Institut für ...
