bonndoc - Der Publikationsserver der Universität Bonn: Recent submissions
Now showing items 21-40 of 12010
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FVIII Trafficking Dynamics Across Subcellular Organelles Using CRISPR/Cas9 Specific Gene Knockouts
(2025-07-01)Factor VIII (FVIII) interacts with Endoplasmic Reticulum (ER) chaperones Calnexin (CANX) and Calreticulin (CALR) and with ER-Golgi Intermediate Compartment (ERGIC) transporters, Lectin, mannose-binding 1 (LMAN1) and Multiple ... -
In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study
(2025-07-24)<strong>Introduction: </strong>Two-stage revision with an antibiotic-loaded, temporary static cement spacer is a common treatment for periprosthetic joint infection (PJI) of the knee. However, limited data exists on in ... -
Peritonsillar abscess in children: A retrospective analysis on surgical and antimicrobial approaches
(2025-07-07)<strong>Background</strong> <br/> Peritonsillar abscess (PTA) is a prevalent infection for specialists in otorhinolaryngology and pediatric primary care providers, that has the potential to cause severe complications. ... -
Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease
(2025-08-26)Autosomal-dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized bymutations in <em>PKD1</em> or <em>PKD2</em>, which drive cystogenesis in renal epithelial cells. Immune cells, particularly macrophages, ... -
A multi-group path analysis of medication documentation quality using cross-sectional survey data: Impact of leadership, job satisfaction, patient-related burnout, and patient safety culture
(2025-09-12)Medication-related adverse events are a major problem for patient safety and quality of care. This study explored the effects of leadership, job satisfaction, patient-related burnout and patient safety culture, measured ... -
Cognitive deficits in treatment-resistant depression: protocol for a systematic review and meta-analysis
(2025-07-03)<strong>Introduction</strong> Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often ... -
Overconfidence and Prejudice
(2025-06-18)We develop a model of multi-dimensional misspecified learning in which an overconfident agent learns about groups in society from observations of his and others' successes. We show that the average person sees his group ... -
Einfluss der lokalen HIFU-Behandlung auf das Überleben bei fortgeschrittenem Pankreaskarzinom
(2025-12-23)<strong>Hintergrund:</strong> Das Pankreaskarzinom ist eine hochaggressive maligne Erkrankung, die aufgrund eines häufig lange asymptomatischen Verlaufs meist erst in einem fortgeschrittenen, inoperablen Stadium diagnostiziert ... -
Standardized Evaluation of Chondrocyte Inflammation Model with TNF alpha
(2025-12-23)This study aimed to develop a standardized chondrocyte inflammation model by evaluating the effects of TNFα concentration and cell passage, and to further refine it into a dynamic model that more accurately reflects ... -
Tenure arrangement, cadastral survey system, and land valuation: addressing tenure insecurity in the aquatic land settlements of Riau Islands Province, Indonesia
(2025-12-22)Riau Islands Province of Indonesia poses a land administration challenge due to its marine setting and culturally rooted coastline settlements. The settlements rapid growth, intricate administration, unclear rights and ... -
Das klinische Outcome von Acetabulumfrakturen: Kraftentwicklung, Lebensqualität und Bewegungsausmaß
(2025-12-19)Acetabulumfrakturen sind selten, jedoch nehmen ihre Inzidenzen in den letzten Jahren, insbesondere bei geriatrischen Patienten, zu. Dies ist auf den demografischen Wandel und veränderte Lebensgewohnheiten zurückzuführen. ... -
Evaluation of personalized video gaming therapy in patients with depression - motivational, behavioral, and neuronal mechanisms
(2025-12-19)This thesis examines the efficacy of personalized video game-based cognitive training (VGT) as an adjunctive treatment in patients with Major Depressive Disorder (MDD), focusing on its motivational, behavioral, and neuronal ... -
Frühgeburtlichkeit und Hüftdysplasie: Eine retrospektive Fall-Kontrollstudie
(2025-12-19)Die primäre oder kongenitale Hüftdysplasie ist eine seltene Erkrankung, die bei etwa 2-4 % der Neugeborenen auftritt. Ohne adäquate Behandlung kann es bereits im frühen Erwachsenenalter zu arthrosebedingten Schmerzen und ... -
Lysosomale Proteine in der Biomarkerforschung: Systematische Analyse klinischer Relevanz und proteomischer Nachweisstrategien
(2025-12-19)Lysosomale Proteine werden zunehmend als potenzielle Biomarker für zahlreiche Erkrankungen diskutiert, ihre zuverlässige Detektion in klinischen Proben stellt jedoch weiterhin eine analytische Herausforderung dar. In dieser ... -
Transitions in the dynamics of recurrent neural networks
(2025-12-18)The brain processes information and performs computations through the collective activity of large populations of interconnected neurons. The dynamics of these biological neural networks can exhibit qualitatively distinct ... -
Entwicklung von neuen Ti-Salen-basierten katalytischen Systemen
(2025-12-18)(noch nicht zugänglich / not yet accessible) -
Amtliche Bekanntmachungen, 55. Jahrgang, Nr. 100
(2025-12-18)Änderungsordnung und zugleich Neubekanntmachung der Promotionsordnung Dr. med. und Dr. med. dent. der Medizinischen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vom 15. Dezember 2025 -
Clustering Trajectories: Detecting Patterns in Spatio-Temporal Data
(2025-12-18)In this thesis, we study the detection of patterns in spatio-temporal data sets in the form of trajectory data. Many application areas collect unstructured trajectory data. Applications for the analysis of such data range ... -
Biochemical and structural characterization of NOD-like receptors and insights into their function in innate immune signaling
(2025-12-17)The human immune system is composed of two main parts, the innate and the adaptive immune system. Pattern recognition receptors (PRRs) present in the innate immune system are capable of recognizing pathogens via ... -
The need for and feasibility of diversification in agriculture: Knowledge production, farming practices, and decision-making
(2025-12-17)Diversification has become a critical strategy in farming systems for mitigating risks, while also providing socio-economic benefits and ecological resilience. However, the dominant conceptualization of diversification in ...
