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Structure and functional characterization of the B-domain and the full-length coagulation factor VIII
(2025-10-29)Factor VIII (FVIII) is a large glycoprotein that serves as a non-enzymatic cofactor for activated Factor IX, facilitating the proteolytic activation of Factor X in the coagulation cascade. Deficiency of FVIII leads to ... -
Periplectic and Isomeric Lie superalgebras, KLR algebras and Categorification
(2025-10-29)We explore the finite dimensional representation theory of the periplectic Lie superalgebra and the isomeric Lie superalgebr, focusing on explicit descriptions of their projective generators' endomorphism rings. Using ... -
Development of intracellular ligands and targeted protein degraders for chemokine receptors and histone deacetylases
(2025-10-29)Chemokine receptors are a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in the immune system by regulating the migration and positioning of immune cells. They are involved in various physiological ... -
Investigation of BRD9 inhibition as alternative treatment option for testicular germ cell tumors
(2025-10-29)Type II germ cell tumors are the most prevalent tumor in young men between the ages of 15 and 35 years. They arise from a block in primordial germ cell differentiation leading to a precursor lesion called germ cell neoplasia ... -
Balancing Biodiversity and Economic Viability: Farmers' Motivations and Challenges in Nature-Protected Areas
(2025-10-29)Biodiversity loss is one of the most urgent environmental challenges, particularly in nature-protected areas (NPAs), where agriculture and conservation come together. Farmers play a central role in land management and can ... -
Describing God?: Christian and Muslim Approaches to the Divine Attributes in Dialogue
(2025)This volume engages traditional and contemporary approaches to the Divine attributes in Christian-Muslim dialogue. A particular focus lies on the attributes of omnipotence and omniscience, justice and mercy, as well as ... -
Literatur und Abtreibung: Von der Romantik bis zur Gegenwart
(2025)Abortions have always existed and will continue to exist – both in real life and in literature. This volume traces the literary history of abortion from the Romantic period to the present day. The contributions deal with ... -
Lateinische Literatur des Barock: Inhalte, Formen und Funktionen
(2025)Der Band enthält 15 Beiträge zur lateinischen Literatur des 17. Jahrhunderts aus mehreren europäischen Räumen (deutscher Sprachraum, Italien, England, Litauen/Polen, Estland, Skandinavien), zu verschiedenen Gattungen (Epos, ... -
Expanding cryospheric landform inventories: quantitative approaches for underestimated periglacial block- and talus slopes in the Dry Andes of Argentina
(2025-05-06)There is a clear spatial discrepancy between the area potentially underlain by permafrost and the landforms recorded in the national inventory of cryospheric landforms in the Dry Andes of Argentina (∼22°–35°S). In the ... -
Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars
(2025-04-10)Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with <em>FGFR2</em> mutations often present dental anomalies in the spectrum of ... -
Alterations in dopaminergic innervation and receptors in focal cortical dysplasia
(2025-04-16)Focal cortical dysplasia (FCD) type 2 is the most common malformation of cortical development associated with pharmaco-resistant focal epilepsy and frequently located in the frontal cortex. Neuropathological hallmarks ... -
The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint
(2025-05-15)Background: Periprosthetic joint infections (PJIs) remain a major challenge in arthroplasty. This study tries to evaluate the PJI-TNM classification as predictor for the revision-free implant survival in patients with PJI ... -
Vom Realen erzählen: Zu einer Konstellation spätmoderner Literatur (1985-2015)
(2025-10-27)Die vorliegende Arbeit unternimmt eine systematische Rahmung und Analyse von Erzähltexten der Spätmoderne bzw. der Gegenwart, die sowohl individuell als auch kollektiv wahrgenommene Krisen und Katastrophen zur Darstellung ... -
Molecular mechanisms affected by boron deficiency in root and shoot meristems of plants
(2025-01-28)Boron deficiency is an abiotic stress that negatively impacts plant growth and yield worldwide. Boron deficiency primarily affects the development of plant meristems— stem cells critical for all post-embryonic tissue growth. ... -
Quality Management Outweighs Pandemic: Retrospective Analysis Shows Improved Quality of Care for Staphylococcus aureus Bacteremia Despite SARS-CoV-2
(2025-03-30)Background: <em>Staphylococcus aureus</em> bacteremia (SAB) is of great clinical relevance, as it is the most common type of bacteremia. Several studies show that the quality of care and thus the outcome can be positively ... -
Intraoperative Profiling of the Supracrestal Implant Complex Minimizes Peri-Implant Crestal Bone Remodeling: The Guided Bone Profiling Concept
(2025-03-08)(1) Background: Early-stage bone resorption following implant placement can significantly impact the long-term success of implants. This study evaluates whether a fully digitally planned implant position based on the E-point ... -
Rhizospheric Bacillus isolates control Fusarium wilt on cotton and enhance plant biomass and root development
(2025-05-02)Cotton is a globally significant crop, serving as a source of natural fiber for the textile industry and contributing to various other products. Its economic importance is substantial, impacting livelihoods and international ... -
Simultaneous selection and displacement of buildings and roads for map generalization via mixed-integer quadratic programming
(2025-03-03)Research on map generalization has led to many algorithms for multiple elementary processes, such as object selection, aggregation, simplification, and displacement. Algorithms for different processes are usually combined ... -
Simulating Soil Moisture Dynamics in a Diversified Cropping System Under Heterogeneous Soil Conditions
(2025-02-06)Agro-ecosystem models are useful tools to assess crop diversification strategies or management adaptations to within-field heterogeneities, but require proper simulation of soil water dynamics, which are crucial for crop ... -
Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana
(2025-03-13)Background/Objectives: Although the COVID-19 pandemic has largely concluded, the varied trajectories it has followed in different regions of the world remain incompletely understood. Intensive research is needed to fully ...
