Browsing by Author "Abdullah, Zeinab"
Now showing items 1-8 of 8
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Characterizing a novel hepatic NK-like T cell population and defining its function during antiviral immune response
(2025-03-24)The family of NK-like (NK1.1+) T cells is extremely heterogeneous, with the most predominant members being the type-I and type-II NKT cells. In addition to that, other unconventional T cells, like gamma-delta T and MAIT ... -
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
(2022-04-22)Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ... -
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury
(2023-03-02)<strong>Background & Aims:</strong> Patients with chronic liver disease (CLD), including cirrhosis, are at increased risk of intractable viral infections and are hyporesponsive to vaccination. Hallmarks of CLD and cirrhosis ... -
Investigating the Role of Nucleic Acid Sensing in the Pathogenesis of Chronic Viral Infection-Induced Chronic Kidney Disease and Autoimmunity
(2025-02-25)Patients with chronic HIV infections, are at increased risk of developing comorbidities, with chronic kidney disease (CKD) such as immune complex glomerulonephritis (ICGN) being particularly common. Diagnosis of ICGN ... -
Obesity impairs virus-specific memory CD8+ T cell signalling and function
(2024-04-11)The main function of the immune system is to protect the host against invading pathogens. Immunological memory is formed after a primary infection and serves to provide protection in a fast and vigorous manner upon secondary ... -
SPI-6 Expression Protects Embryonic Stem Cells from Lysis by Antigen-Specific CD8+ Cytotoxic T Lymphocytes
(2008)Embryonic stem (ES) cells are defined by their capacity of self renewal and the potential to give rise to any differentiated cell type of the entire organism. These properties have made ES cells promising tools for future ... -
Strategies to recover liver regeneration after partial hepatectomy in obese mice
(2025-02-07)Liver regeneration is vital for recovering liver function after surgical resection or transplantation. Using a mouse model for HpX, we were capable of identifying the role of different subsets of hepatic macrophages during ...
