Browsing by Subject "P-gp"
Now showing items 1-3 of 3
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Optimierung der Aufreinigung und Rekonstitution von humanem P-Glykoprotein in S. cerevisiae zur Charakterisierung neuer Modulatoren
Sievers, Jürgen Gerhard (2007)P-Gp ist eine ca. 170 kDa großes Protein, das aus zwei homologen Hälften besteht. Jede homologe Hälfte enthält jeweils sechs a-Helix transmembranäre Domainen und eine Nukleotid-Bindungsstelle im Zytoplasma. Für P-Gp werden ... -
Purines and 9-deazapurines as Modulators of Multidrug Resistance-associated Protein 1 (MRP1/ABCC1)-mediated Transport
Schmitt, Sven Marcel (2017-11-14)Expression of ABC-transport proteins is a major obstacle in cancer chemotherapy. Especially MRP1, P-gp and BCRP are expressed in different malignancies like lung cancer, colon carcinomas, leukemias, bladder cancer, myeloma, ... -
Structural conformational analysis of molecular dynamics of a P-glycoprotein homology model and generated intermediate structures
Hafner, Melanie Salome (2019-10-02)The major reason for failure of chemotherapy in cancer is multidrug resistance. A mechanism by which human cancers develop multi-drug resistance is over expression of certain ATP-binding cassette (ABC) transporters. ...