Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 51-60 von 215
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
(2022-02-02)
Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ...
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...
Investigation of the procoagulant role of labile heme under hemolytic conditions
(2021-07-19)
Severe intravascular hemolysis leads to the excessive release of labile heme into the vascular compartment, thereby overwhelming the heme-binding capacity of the protective heme- scavenging system. As a consequence, labile ...
Structural and functional characterization of TRAP transporters from bacterial pathogens
(2021-08-26)
The class of tripartite ATP-independent periplasmic (TRAP) transporter proteins are wide-spread in the kingdoms of prokaryotes and archaea, where they are responsible for translo-cation of substrates across the cell membrane. ......
Interesse an Pflanzen fördern: Eine Design Based Research-Studie mit Kindern und Jugendlichen
(2022-01-27)
Obwohl Pflanzen für unsere Ökosysteme unverzichtbar sind, ist das Interesse an diesen Lebewesen bei vielen Menschen gering. Die Förderung des Interesses an Pflanzen scheint von besonderer Bedeutung, zumal das Interesse an ...
Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation
(2020-10-02)
Serine proteases represent the largest group of enzymes of the human degradome. As such, they are valuable targets for the development of new drugs, due to their involvement in several diseases. Over the course of this ...
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
(2020-02-07)
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a ......
Petrological analyses and Lu-Hf geochronology of subducted continental and oceanic crust from different locations in the upper and lower plate of the Caledonian Orogen
(2020-03-09)
In this thesis I conducted Lu-Hf analyses on samples from locations all over the Caledonian Orogen. I combined these ages with petrological analyses in order to help to unravel some of the open questions concerning the ...
The role of cytohesins in the regulation of immune responses
(2020-02-17)
Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in vitro ......
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...