Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 371-380 von 405
MicroRNAs and orphan nuclear receptor GCNF as novel regulators of human neural stem cell differentiation and neuronal subtype specification
(2015-10-22)
MicroRNAs (miRNAs) are currently recognized as important regulators of neural development. However, given the large number of miRNA species in existence, our understanding of miRNA-based regulation during neurogenesis ...
Potential of Complementary Methods for the Authentication of Herbal Substances and their Mixtures
(2015-10-22)
Herbal substances and preparations thereof play an important role in healthcare systems worldwide. An essential prerequisite for the safe and effective use of herbal medicines is the unequivocal identification of the plant ...
Oxytocin – the prosocial molecule?: Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
(2015-10-30)
Oxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting ...
Chemical modifications of DNA activate the cGAS/STING-signaling pathway even in the presence of the cytosolic exonuclease TREX1
(2015-09-16)
To recognize pathogen threats, the innate immune system is equipped with pattern recognition receptors (PRRs) that bind to and are activated by pathogen-associated molecular patterns (PAMPs). Most PAMPs are conserved across ...
Direct and indirect cholinergic septo-hippocampal pathways cooperate to structure spiking activity in the hippocampus
(2015-10-09)
The medial septum/vertical diagonal band of Broca complex (MSvDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSvDB play a central role in generating and pacing theta-band ...
Immune modulation by experimental filarial infection and its impact on E. coli-induced sepsis
(2015-11-12)
Helminths cause so-called neglected tropical diseases in tropical and sub-tropical regions and are prevalent in almost one third of mankind. Thus, co-infections of helminths with other pathogens are common. However, the ......
A high-resolution regional reanalysis for Europe and Germany: Creation and Verification with a special focus on the moisture budget
(2015-10-22)
Atmospheric reanalyses represent a state-of-the-art description of the Earth‘s atmospheric state over the past years or decades. They are comprised of a numerical model for the solution of the equations of motion describing ...
The Influence of the Xin Repeat-Containing Proteins on the Development of Pressure Induced Cardiac Hypertrophy in Mice
(2015-10-16)
The proteins of intercalated discs (ICDs) are components of the cardiac cytoskeleton which forms the scaffold of cardiomyocytes and thus helps to maintain cell shape, provide tissue integrity, and to stabilize the sarcomeric ...
Investigation of the role of microRNAs in Spinocerebellar Ataxia type 3
(2015-10-30)
Spinocerebellar Ataxia Type 3 (SCA3) is an inherited, neurodegenerative disorder belonging to the group of polyglutamine repeat disorders. It is caused by CAG repeat expansions in the ATXN3 gene leading to expanded ...
Dynamic Difficulty Adjustment
(2015-10-30)
One of the challenges that a computer game developer faces when creating a new game is getting the difficulty right. Providing a game with an ability to automatically scale the difficulty depending on the current player ...