Faculties of University Bonn: Search
Now showing items 31-40 of 92
Propagation of Tau pathology in Alzheimer disease
(2020-09-10)
Clinical and experimental evidences suggest that the spreading of tau protein throughout the brain may underlie the stereotypical progression of pathology in the brains of Alzheimer disease (AD) patients and concomitant ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Fettsäure-unabhängige Anpassung bakterieller Membranen an niedrige Temperaturen
(2020-07-01)
Nach dem bisherigen Kenntnisstand der Forschung erfolgt die Kälteadaptation der bakteriellen Zellmembran durch die Änderung der Fettsäurezusammensetzung. In dieser Arbeit wurden Lebensmittel-assoziierte Isolate, deren ......
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
(2020-11-16)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ...
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...
The mechanisms of stress memory responses and translational regulation during dehydration and rehydration in the resurrection plant Craterostigma plantagineum
(2020-05-25)
Dehydration stress is one of the major environmental factors affecting the survival rate and productivity of plants. Currently, many dehydration-induced genes and some dehydration-related protective mechanisms desiccation ......
Toward a precision medicine in Alzheimer’s Disease: blood phenomic fingerprint for diagnostic and therapeutic developments
(2020-05-05)
There is an unmet clinical need to identify reliable blood biomarkers for Alzheimer’s Disease (AD) that can be used for diagnostics and therapeutic purposes.
The complex nature of AD, single-readout approaches ......
The complex nature of AD, single-readout approaches ......
Influence of cyclic mechanical strain on tissues of the central nervous system
(2020-12-17)
Although the brain is the softest tissue of the human body, cells embedded in the brain are responding to physiological mechanical cues. Tissue homeostasis is, therefore, not only dependent on chemical cues (e.g. growth ...
The Acyl-ACP Thioesterase FatM from Lotus japonicus is involved in lipid transfer during Arbuscular Mycorrhiza Symbiosis
(2020-01-27)
Arbuscular mycorrhiza colonization of roots is an ancient symbiosis that presumably was involved in the conquest of the land by early plants. Its main benefit for plants is the increased access to soil mineral nutrients ...