Fakultäten der Universität Bonn: Suche
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The Phenomenon of Functional Retention of Incorporated Chloroplasts in Sea Slugs (Sacoglossa, Heterobranchia, Mollusca) and Evolutionary Adaptations: Aspects of Photobiology, Cell Biology, Ecology and Behavior
(2020-01-30)
The phenomenon of retention of functional chloroplasts from their food algae in sacoglossan sea slugs - also called kleptoplasty - is a challenge for research, still leaving many questions unsolved, e. g. concerning ......
The Functions of Literature: A Diachronic Perspective on the British Novel on Terrorism from the Victorian Fin de Siècle to the Present
(2020-04-15)
Modern terrorism emerged over 150 years ago. It not only wreaked havoc on individuals and societies and inspired widespread fear of future attacks, but also triggered a myriad of fictional responses by writers and film-makers, ...
Petrological analyses and Lu-Hf geochronology of subducted continental and oceanic crust from different locations in the upper and lower plate of the Caledonian Orogen
(2020-03-09)
In this thesis I conducted Lu-Hf analyses on samples from locations all over the Caledonian Orogen. I combined these ages with petrological analyses in order to help to unravel some of the open questions concerning the ...
Modelling melanoma control by immunotherapy and tissue-resident memory T cells using CRISPR/Cas9-based approaches
(2020-02-03)
In recent years, immunotherapy has demonstrated remarkable efficacy in the treatment of metastatic melanoma due to the development of T cell-based therapies such as checkpoint inhibitors or adoptive T cell transfer therapy ......
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)
Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ...
Investigating the molecular basis of human NLRP1 inflammasome activation
(2020-03-10)
Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ...
The role of T cell help in shaping Dendritic Cell function
(2020-02-07)
CD8+ T cell priming depends on antigen presentation by dendritic cells (DCs) and their capacity to communicate contextual cues associated with antigen acquisition. DCs often also require additional signals from ......
The role of cytohesins in the regulation of immune responses
(2020-02-17)
Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in vitro ......
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...
Neuroinflammation, microglia and the cell biology of Alzheimer's Disease
(2020-04-08)
The pathology of Alzheimer’s disease (AD) is characterised by progressive accumulation of misfolded proteins, which form senile plaques and neurofibrillary tangles, and chronic inflammation in the brain associated with ...