Faculties of University Bonn: Search
Now showing items 1-10 of 86
Ai-based, behavior dependent approaches for connectomic reconstruction of neuronal circuits
(2022-03-24)
Characterizing the functional architecture of neuronal circuits that underly complex behavior requires identifying active neuronal ensembles during behavioral expressions of interest. The recent development of light-induced, ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Functional analysis of the endocannabinoid system in conditional mouse mutants
(2020-09-04)
In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ...
Die Phyllosphäre als Lebensraum für Bakterien: Mechanismen der Interaktion epiphyller Bakterien mit der pflanzlichen Kutikula
(2020-12-16)
Die Phyllosphäre stellt einen lebensfeindlichen Lebensraum dar. Jedoch gibt es epiphytisch lebende Bakterien, die diesen Lebensumständen entgegenwirken und Mechanismen entwickelt haben, in diesem kargen Lebensraum Nährstoffe ......
Combining Fluorescence and Reflectance to Quantify Dynamics in Photosynthetic Regulation
(2021-12-14)
Photosynthesis in the field is anything but steady-state. Because environment is changing, understanding plant’s photosynthetic activity in situ is challenging. Measurement of solar-induced fluorescence (SIF), along with ......
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina
(2021-07-13)
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und ...
Identification, characterisation, and evaluation of bioactive plant-based compounds for the sustainable stabilisation of food packaging materials
(2022-04-05)
Typically, plastic packaging materials are produced using additives, like e.g. stabilisers, to introduce specific desired properties into the material or, in case of stabilisers, to prolong the shelf life of such packaging ......
Identifizierung, Charakterisierung und Evaluierung von bioaktiven sekundären Inhaltsstoffen für die nachhaltige Stabilisierung von Lebensmittelverpackungen
Kunststoffverpackungen werden üblicherweise ......
Identifizierung, Charakterisierung und Evaluierung von bioaktiven sekundären Inhaltsstoffen für die nachhaltige Stabilisierung von Lebensmittelverpackungen
Kunststoffverpackungen werden üblicherweise ......
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...