Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 61-70 von 88
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
(2023-06-21)
Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ...
The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
(2023-03-29)
The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ...
Inhibition of heterotrimeric Gs proteins by FR900359 - more than a simple transfer of the inhibitor binding site
(2023-03-07)
A plethora of vital functions of the human body, including blood pressure, cell proliferation and metabolism are regulated by G protein-mediated signaling cascades. These cascades form a complex network of cause and effect ...
Investigating pathomechanisms underlying malformations of human cortical development
(2023-06-15)
During human development the brain has to form a complex neuronal network requiring a well-orchestrated sequence of neurogenesis, neuronal migration and correct positioning within cortical layers followed by synaptogenesis. ...
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...