Faculties of University Bonn: Search
Now showing items 241-250 of 262
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
I) Characterization of LytR-CpsA-Psr enzymes and their role in Staphylococcus aureus cell wall formation
II) Elucidating the mode of action of Cacaoidin, a novel class V lantibiotic
(2022-04-04)
Antibiotic resistance poses a serious threat to human health, demanding for the discovery and development of antibiotics with resistance-breaking properties. New antibiotics should be sought with the focus on novel chemistry ...
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Mechanisms underlying the effects of context on food decisions in humans
(2023-05-25)
Food decisions are inevitable, frequent, and complex decisions with a high impact on our health. Understanding the mechanisms that underly food decisions has become a multidisciplinary endeavor over the last decades, ...
Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
(2023-06-21)
Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ...
Direkte pharmakologische Gq-Protein-Modulation in pulmonalen Gefäßen
(2023-04-04)
Heterotrimere G-Proteine können in vier Familien entsprechend ihrer alpha-Untereinheit unterteilt werden (Gs, Gi, G12/13 und Gq). Sie überführen ein extrazelluläres Signal nach der Aktivierung von G-Protein-gekoppelten ......