Faculties of University Bonn: Search
Now showing items 101-110 of 142
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
(2023-06-21)
Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ...
The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
(2023-03-29)
The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...