Faculties of University Bonn: Search
Now showing items 111-120 of 142
The interplay of fatty acid synthesis, metabolism, and immune function during Flavivirus infection
(2023-10-04)
Macrophage activation and Flavivirus infection can both fundamentally alter cellular metabolism and change the lipid landscape of cells. Flaviviruses upregulate fatty acid synthesis to build membranous replication complexes, ...
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
(2023-12-07)
Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ...
Deciphering the role of human-specific genes in the development of the human neocortex
(2024-01-04)
The human brain is remarkably complex and has been subject to noteworthy changes throughout evolution. An expansion of progenitor cells is thought to contribute to the complexity and increase in cortical size that is ......
Platelets shape the immune response of primary human monocytes
(2023-01-13)
Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...
Programmed cell death regulation during Salmonella Typhimurium infections
(2024-01-18)
Programmed cell death (PCD) is a highly regulated process that is vital for the development and homeostasis of multicellular organisms. It functions as an essential mechanism to remove dispensable or unfavourable cells in ......
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Role of GluA2-containing AMPARs in Oligodendrocyte Lineage Cells
(2024-01-30)
Oligodendrocytes precursor cells (OPC), also called NG2 cells, proliferate or differentiate into myelin-producing oligodendrocytes throughout life. Myelination depends on neuronal activity. Although NG2 cells receive ...
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...
Danger signaling pathways in aortic disease
(2024-02-19)
The aorta connects the heart to the peripheral circulation and organs. It is necessary for the regulation of hemodynamics and therefore, aortic disease affects all organs and the survival of the individual. In aortic valve ...