Faculties of University Bonn: Search
Now showing items 121-130 of 142
Physical activity and fitness for healthy ageing
(2024-02-19)
The proportion of individuals suffering from age-associated noncommunicable diseases is expected to rise rapidly in the next decades. To maintain health, well-being and socioeconomic stability in an ageing society, identifying ...
Sphingosine-1-phosphate receptor 3 signaling is a critical modulator of stroke outcome
(2022-08-29)
Stroke is a leading cause of long-term disability worldwide. Its highly complex pathogenesis is characterized by a deleterious cycle of vascular dysfunction and inflammation. Recently, the bioactive phospholipid ......
Optogenetische Stimulation des nativen Herzmuskels durch Adeno-assoziierte Virustransduktion von Channelrhodopsin-2
(2022-12-15)
Die Optogenetik ist eine innovative Methode, die die transgene Expression von lichtsensitiven Proteinen verwendet zur elektrophysiologischen oder biochemischen Stimulation von Zellen durch Beleuchtung. Das Beleuchten mit ......
Recognition of orthoflaviviral RNA in mosquitoes and viral countermeasures
(2024-02-26)
Various infectious diseases are caused by mosquito-borne orthoflaviviruses affecting people worldwide. Efficient transmission of these viruses highly depends on the pathogen’s ability to overcome the host immune system. ...
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
Immune activation by DNA sensors in ANCA associated vasculitis
(2024-03-04)
Anti-neutrophilic cytoplasmatic antibody (ANCA) associated vasculitis (AAV) is a group of rare inflammatory autoimmune diseases primarily affecting the small vessels of kidney and lung. Current treatment options mainly ...
Analysis of reprogramming-associated alterations using an isogenic human stem cell system
(2022-03-04)
Human induced pluripotent stem cells (iPSCs) could provide a valuable tool for the production of specific somatic cell types for disease modeling or cell replacement. Considering the molecular complexity of the reprogramming ...
Influence of the Fatty Acid Saturation Levels on Inflammatory Signalling in Melanoma Cells
(2023-09-11)
Due to their rapid proliferation, tumour cells have an enhanced demand for lipids. Therefore, increased lipogenesis is considered as a hallmark of cancer. In melanoma, the lineage addiction oncogene MITF regulates the ...
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...
Validation, determinants and impact of medication use
(2024-04-02)
In recent decades, global medication consumption has increased substantially due to an aging population and more emphasis on preventative treatment. As medication use increases, concerns naturally arise regarding the ...