Faculties of University Bonn: Search
Now showing items 1211-1220 of 1327
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...
Function of RIM4 in cerebellar circuits
(2023-12-18)
(noch nicht zugänglich / not yet accessible)
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......
Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
(2023-06-21)
Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ...
AI Models for Modeling and Simulation of Clinical Studies for Alzheimer's and Parkinson's Disease
(2023-08-14)
Neurodegenerative diseases (NDDs) have a complex structure and most of them are untreatable that’s why more research studies undertake translational paths for getting better insights into prevention, early detection, and ...
Integrated structural biology investigation of the bacterial TRAP transporter SiaPQM from pathogenic bacteria
(2023-10-31)
Sialic acid is utilized by human pathogens like Vibrio cholerae in various ways to colonize the host. Upon contamination it scavenges the sialic acid from mucus-rich parts of the body such as the gut and causes the disease ......
Dynamics of group II introns in plant mitogenomes and rickettsial DNA invasions in the mitogenome of Haplopteris ensiformis
(2023-07-27)
The complexity of mitochondrial genomes (mtDNA) in vascular plants is well-known, with factors such as repetitive sequences, variable structural organization, gene synteny decline, high intron content, and RNA editing ...