Fakultäten der Universität Bonn: Suche
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The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
(2023-03-29)
The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ...
Mechanical strain influence on functional signaling of neurons in vitro
(2023-02-22)
Neuronal cells are embedded in the soft brain tissue and are protected by the thick meninges, as well as the rigid skull bones. Despite being highly sensitive and vastly protected, neurons are prone to internal and external ...
Inhibition of heterotrimeric Gs proteins by FR900359 - more than a simple transfer of the inhibitor binding site
(2023-03-07)
A plethora of vital functions of the human body, including blood pressure, cell proliferation and metabolism are regulated by G protein-mediated signaling cascades. These cascades form a complex network of cause and effect ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...
Investigating pathomechanisms underlying malformations of human cortical development
(2023-06-15)
During human development the brain has to form a complex neuronal network requiring a well-orchestrated sequence of neurogenesis, neuronal migration and correct positioning within cortical layers followed by synaptogenesis. ...
Identification and characterization of evolutionarily conserved inositol pyrophosphate phosphohydrolases in plants
(2023-10-27)
Inositol phosphates (InsPs), phosphate esters of myo-inositol, are cellular regulators with critical roles in a wide range of cellular processes in eukaryotes. Members of the subgroup containing at least one ‘high-energy’ ......
Complement receptors 3 and 4 in kidney diseases
(2023-12-11)
CR3 and CR4 are among the most abundant molecules on the cell surface of DCs, monocytes/macrophages, and PMNs. Both integrins recognize common ligands among which are iC3b, ICAM-1, and fibrinogen. iC3b is generated as a ......
Investigating the effects of sphingosine-1-phosphate lyase (SGPL1) ablation in mouse embryonic fibroblasts and primary astrocytes
(2023-09-13)
Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays a crucial role in various fundamental processes, including cellular proliferation, survival, migration, as well as inflammation. Additionally, it has been ......
The interplay of fatty acid synthesis, metabolism, and immune function during Flavivirus infection
(2023-10-04)
Macrophage activation and Flavivirus infection can both fundamentally alter cellular metabolism and change the lipid landscape of cells. Flaviviruses upregulate fatty acid synthesis to build membranous replication complexes, ...
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
(2023-12-07)
Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ...