Fakultäten der Universität Bonn: Suche
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The Synaptic Basis of Binocular Alignment and its Development in Ferret Primary Visual Cortex
(2023-12-01)
The brain integrates information from a myriad of external stimuli to generate a rich but consistent representation of the world and instruct behavior. For coherent binocular vision, signals from both eyes need to be ...
Cryo-EM structures of the human NLRP3 inflammasome
(2023-11-20)
NLRP3 is an intracellular sensor protein whose activation by a broad spectrum of exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis. The mechanisms leading to NLRP3 activation and the way how ...
Characterization of the immune system-drug interactions during anti-filarial treatment in the Litomosoides sigmodontis mouse model
(2024-01-03)
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Both diseases are included in the list of neglected tropical diseases as defined by the World Health Organization (WHO) ......
Deciphering the role of human-specific genes in the development of the human neocortex
(2024-01-04)
The human brain is remarkably complex and has been subject to noteworthy changes throughout evolution. An expansion of progenitor cells is thought to contribute to the complexity and increase in cortical size that is ......
Sleep and navigation in Drosophila
(2023-12-20)
Sleep plays an essential role in life and is critical for the optimal functioning of the brain, for example in learning and memory. Drosophila displays many of the signatures of sleep observed in mammals or humans, including ...
Characterisation of Inflammasome-Induced Extracellular Vesicles, Their Uptake by and Effect on Bystander Cells
(2023-12-22)
Inflammasomes are multimeric complexes whose activation triggers caspase 1 cleavage resulting in processing of the cytokines interleukin (IL) 1β and IL-18, and the pore-forming protein gasdermin D. This, in turn, initiates ...
Neural mechanisms involved in visual learning in the cichlid fish Pseudotropheus zebra
(2023-12-20)
Although several studies have investigated the cognitive abilities in fish, not so much is known about where the cognitive information is processed in the brain. For this PhD thesis I assessed visual learning and its neural ......
Programmed cell death regulation during Salmonella Typhimurium infections
(2024-01-18)
Programmed cell death (PCD) is a highly regulated process that is vital for the development and homeostasis of multicellular organisms. It functions as an essential mechanism to remove dispensable or unfavourable cells in ......
ESCRT in der Makrophageninfektion durch Rhodococcus equi
(2024-01-22)
(noch nicht zugänglich / not yet accessible)
Cellular and molecular defence mechanisms against Legionella infection
(2024-01-26)
The two most prevalent causes of Legionnaires’ disease are L. pneumophila and L. longbeachae. The rising incidence of the Legionnaires’ disease over the past two decades together with the increasing prevalence of L. ......