Fakultäten der Universität Bonn: Suche
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Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)
The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ...
Analysis of reprogramming-associated alterations using an isogenic human stem cell system
(2022-03-04)
Human induced pluripotent stem cells (iPSCs) could provide a valuable tool for the production of specific somatic cell types for disease modeling or cell replacement. Considering the molecular complexity of the reprogramming ...
Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma
(2023-03-07)
Gastric cancer (GC) is a clinically heterogeneous and one of the most common malignant tumour entities affecting the human gastrointestinal tract with a multifactorial aetiology. Beside environmental risk factors, also ...
Influence of the Fatty Acid Saturation Levels on Inflammatory Signalling in Melanoma Cells
(2023-09-11)
Due to their rapid proliferation, tumour cells have an enhanced demand for lipids. Therefore, increased lipogenesis is considered as a hallmark of cancer. In melanoma, the lineage addiction oncogene MITF regulates the ...
Validation, determinants and impact of medication use
(2024-04-02)
In recent decades, global medication consumption has increased substantially due to an aging population and more emphasis on preventative treatment. As medication use increases, concerns naturally arise regarding the ...
Invasion biology of amphibians and reptiles: From observations to predictive spatial models
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
Molecular Characterization of Quality Control Factors at the Protein Entry Gate of Mitochondria
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
(2020-10-12)
DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. ......
Detecting G4 unwinding
(2022-04-18)
DNA can, in addition to the B-DNA conformation, fold into a variety of additional conformations. Among them are G-quadruplex structures that have gained a lot of attention in recent years. G-quadruplex structures (G4s) are ...
Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
(2012-05-01)
DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed ...