Faculties of University Bonn: Search
Now showing items 121-125 of 125
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Biomarkers and Correlates of Aging
(2021-10-19)
The rapid aging of the global population, often accompanied by disabilities and various age-related diseases, is becoming a major public health burden (WHO 2015). Stimulating healthy aging is therefore of tremendous ...
Structural and Functional Changes in the Cerebellum in Sporadic Ataxias
(2021-01-26)
Sporadic ataxia is a group of progressive neurodegenerative diseases that can be subdivided into two groups, sporadic adult onset ataxia (SAOA), and the cerebellar type of multiple system atrophy (MSA-C). In the first years ...
Enemy or ally? Fasting as an essential regulator of immune responses
(2021-04-14)
Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are emerging as a central aspect of ...