Fakultäten der Universität Bonn: Suche
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Rare Disease Spina Bifida: A Retrospective Cost of Illness Analysis of Patients in Germany Between 2017 and 2020
(2024-02-14)
Background: Spina bifida (SB), as a rare non-curable disease with comorbidities, requires multi-professional collaboration. Less is known about patient journeys, medical costs, health-related quality of ...
Los Señores del río y las lagunas: trabajo, epidemia y muerte entre los malebues del río Magdalena (Colombia): 1530-1611
(2024-03-28)
Para el año de 1611, los Indios Navegantes o malebues del río Magdalena (norte de Colombia) en gran parte habían desaparecido. Según los resultados, el descenso de población había alcanzado el 97%; las poblaciones padecían ...
Novel Methods for Chiral Molecules in the Gas Phase and Neoteric Solvents
(2024-03-19)
This thesis focuses on the development and application of computational methods for the calculation of infrared (IR) and vibrational circular dichroism (VCD) spectra in the gas and liquid phase, with special emphasis on ...
Optimal Numerical Basis Functions in the Partition of Unity Method
(2024-04-08)
Partial differential equations (PDE) arise from the modeling of a wide range of physical problems and knowing how to solve them is of large interest in many industrial undertakings. One numerical method to solve PDE is the ...
The role of the NLRP3 inflammasome in microglial senescence in tauopathies
(2024-03-12)
Background: Tauopathies including Alzheimer’s Disease and Frontotemporal Dementia are neurodegenerative disorders characterized by abnormal tau accumulation. Senescent cells, which present with a potentially ...
Epidemiologic analyses of large-scale ophthalmic datasets
(2024-03-06)
In this thesis different epidemiological approaches were used to gather and evaluate various large datasets in order to address specific research questions in the field of ophthalmology. According to the individual research ...
Developmental programming of adipose tissue by maternal obesity
(2024-03-25)
Tissue-resident macrophages are an integral part of the innate immune system, but their biology is not well understood in the context of metabolic diseases. Distinctive Resident macrophage populations are identified in ...
Protein markers of inflammation and ageing in a European multi-centre dementia cohort
(2024-03-01)
Inflammation plays a key role in Alzheimerʼs disease (AD) progression. Microglia in the AD brain are exposed to pathological amyloid β (Aβ42) and tau peptide aggregates, resulting in the NLRP3 inflammasome activation ...
Organization principles of thalamocortical input onto deep-layer inhibitory neurons of the barrel cortex
(2024-02-28)
Thalamus functions as the main route by which incoming sensory information reaches the cerebral cortex. Thalamic nuclei will receive input from the sensory receptors in the periphery and relay it to different areas in the ...
Prävalenz der Aufmerksamkeitsdefizits-/Hyperaktivitätsstörung bei Menschen mit einer substanzbezogenen Störung: Eine Metaanalyse
(2024-03-12)
Substanzbezogene Störungen (SUD) haben erheblichen Einfluss auf unser Gesundheits-system. Die Hospitalisierung von Patient*innen mit einer SUD geht oft mit Komplikationen einher und hat in den letzten Jahren zugenommen. ...