Fakultäten der Universität Bonn: Suche
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Influence of High-Pressure Compaction of Binary Mixtures on Solubility, Dissolution and Wettability of Borderline Poorly Soluble Drugs Employing Standard Excipients
(2021-12-14)
Many of new drug candidates are impaired by low aqueous solubility and slow dissolution rates, which may hinder their pharmacological response. Therefore, there is an increasing need to investigate and implement new ...
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Measurement of the double polarization observables G and E in neutral and positive pion photoproduction off the proton
(2020-08-14)
The nucleons, as one of the most fundamental building blocks of visible matter, are built up of quarks and gluons. However, the interactions and dynamics inside the nucleons, which are mediated by the strong force and ......
Multi-stage Micropattern Gaseous Detectors for the ALICE TPC Upgrade - Studying and Modelling Charge Transfer and Energy Resolution
(2020-06-23)
With the upgrade of the LHC (Large Hadron Collider) at CERN, the interaction rate of ALICE
(A Large Ion Collider Experiment) will be increased up to 50 kHz for Pb-Pb collisions.
Thus the gated and rate-limited readout ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Functional analysis of the endocannabinoid system in conditional mouse mutants
(2020-09-04)
In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ...
Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof
(2021-05-19)
The poor solubility of existing drug substances and new chemical entities is a problem in modern pharmaceutical development. There are various strategies to overcome the solubility limited bioavailability of poorly soluble ...
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)
The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ......
Die Phyllosphäre als Lebensraum für Bakterien: Mechanismen der Interaktion epiphyller Bakterien mit der pflanzlichen Kutikula
(2020-12-16)
Die Phyllosphäre stellt einen lebensfeindlichen Lebensraum dar. Jedoch gibt es epiphytisch lebende Bakterien, die diesen Lebensumständen entgegenwirken und Mechanismen entwickelt haben, in diesem kargen Lebensraum Nährstoffe ......