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The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)
In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...