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Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
(2022-12-21)
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and ...
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
(2022-11-15)
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 ...
COVID-19 and changes in global agri-food trade
(2022-04-09)
COVID-19 has raised questions about the resilience of agri-food trade to global shocks to the system. This paper analyses the changes in agri-food trade (values, extensive and intensive margin, and diversification) during ...
Effects of Different Titanium Surface Treatments on Adhesion, Proliferation and Differentiation of Bone Cells: An In Vitro Study
(2022-09-05)
The objective of this study was to evaluate the impacts of different sandblasting procedures in acid etching of Ti6Al4V surfaces on osteoblast cell behavior, regarding various physicochemical and topographical parameters. ...
Neural Correlates of Smooth Pursuit Eye Movements in Schizotypy and Recent Onset Psychosis: A Multivariate Pattern Classification Approach
(2022-06-03)
Schizotypy refers to a set of personality traits that bear resemblance, at subclinical level, to psychosis. Despite evidence of similarity at multiple levels of analysis, direct comparisons of schizotypy and clinical ...
Mini Review: The Forensic Value of Heat Shock Proteins
(2022-01-10)
Forensic pathologists are routinely confronted with unclear causes of death or related findings. In some instances, difficulties arise in relation to questions posed by criminal investigators or prosecutors. Such scenarios ...
Multimodal Virtual Reality-Based Assessment of Adult ADHD: A Feasibility Study in Healthy Subjects
(2022-04-18)
Neuropsychological assessments are often surprisingly inaccurate in mapping clinically-reported attention-deficit hyperactivity disorder (ADHD) symptoms, presumably due to their low ecological validity. Virtual ...
Sympathetic Innervation Modulates Mucosal Immune Homeostasis and Epithelial Host Defense
(2022-08-21)
Intestinal mucosal cells, such as resident macrophages and epithelial cells, express adrenergic
receptors and are receptive to norepinephrine, the primary neurotransmitter of the sympathetic
nervous system (SNS). It has ...
Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ...
Misfit of Complete Maxillary Dentures’ Posterior Palatal Seal following Polymerisation with Four Different Autopolymerising Resins: An In Vitro Study
(2022-07-30)
Background: The majority of complete dentures are still conventionally manufactured using a flask-and-pack technique. However, the polymerization process may introduce a distortion of the denture body. The aim of this study ...