Fakultäten der Universität Bonn: Suche
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Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina
(2021-07-13)
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und ...
Biochemical and Structural Characterization of β-Hydroxylases in Non-Ribosomal Peptide Biosynthesis
(2022-02-02)
Hydroxylases are essential in the biosynthesis of natural products by functionalization of building blocks, which derive from primary metabolism. They provide hydrophily for specific interactions or enable further ...
Investigations on Marine Natural Products from Indo-Pacific Nudibranchia (Mollusca: Gastropoda): Chemoecology, Medicinal Potential & Toxin Resistance
(2022-03-22)
This thesis focusses on the investigation of marine natural products (MNPs) from nudibranchs of the Central Indo-Pacific Ocean and their food sources. MNPs are important lead structures in the drug discovery process, as ......
Talentierte symbiontische Naturstoffproduzenten als Quelle neuer Wirkstoffe
(2020-03-03)
Zunehmende Resistenzen und gleichzeitig sinkende Zahlen neu zugelassener Antibiotika lassen den Bedarf an neuen antibiotischen Wirkstoffen steigen. Aber auch in anderen medizinischen Bereichen wie z. B. der Onkologie ist ...
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......