Auflistung nach Schlagwort "T cells"
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Aptamers for targeted activation of T cell-mediated immunity
Haßel, Silvana Katharina (2016-09-19)An attractive way of preventing or curing infections and diseases is to mobilize patient’s own defense mechanisms, the immune system. Treatments following this approach are commonly known as immunotherapies. The development ... -
Charakterisierung der Veto-Funktion von hepatischen Sternzellen
Schildberg, Frank Alexander (2012-08-01)Die Leber spielt eine entscheidende Rolle bei der Induktion der T-Zell-Toleranz. Diese wird insbesondere durch die Funktionen von tolerogenen hepatischen Antigen-präsentierenden Zellen und regulatorischen T-Zellen erzielt. ... -
Nanoparticle delivery of molecular agents to tackle HIV latency
Ali, Abdalla Abbas Jafer (2022-09-16)Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4+T cells is a significant ... -
Recognition of cytosolic 3´P DNA & The role of GCET2+ DCs in cross-presentation
Schmitt, Sven (2020-04-01)In mammalian cells, DNA is confined to the nucleus and mitochondria. Detection of DNA in other compartments like the cytoplasm indicates danger and infection. Our research group has previously discovered that 3´monophosphate ... -
Regulation of innate and adaptive immune responses by Toll-like receptor ligands
Schumak, Beatrix (2008)Toll-like receptors (TLR) recognize conserved molecular patterns of microorganisms and are essential for the activation of host immunity. Whereas the immune-stimulatory effects of TLR ligands are well described, the ... -
Return of the first inflammasome: Elucidation of NLRP1 inflammasome activation by p38-mediated phosphorylation and ubiquitination
Jenster, Lea-Marie (2024-01-30)The assembly of inflammasomes is linked to the detection of pathogens and other danger signals by intracellular pattern-recognition receptors of the mammalian innate immune system. The human inflammasome sensor NLRP1 is ... -
The role of cytohesins in the regulation of immune responses
Solomatina, Anastasia (2020-02-17)Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in ...