Faculties of University Bonn: Browsing Fakultäten der Universität Bonn by Title
Now showing items 5284-5303 of 8299
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Novel aspects regarding structural variability in membrane protein families by the example of tetraspanins
Reppert, Nikolas (2022-11-16)The work at hand focuses on structural variability in membrane protein families by the example of tetraspanins. The family of tetraspanins is found in almost all multicellular organisms and they play important roles in an ... -
Novel Heterobimetallic Manganese-Chromium and Rhenium-Chromium Complexes: Coordination, Cyclometallation, Benzannulation and Haptotropic Metal Migration
Dubarle Offner, Julien (2009-03-23)A characteristic property of transition metal π-complexes with polycyclic aromatic ligands is their ability to undergo haptotropic rearrangements; the metal fragment is considered as the moveable functional group that is ... -
Novel insights into mechanisms and selectivity of the heterotrimeric G protein inhibitors BIM-46187 and FR900359
Schmitz, Anna-Lena (2015-04-24)Selective silencing of Gα protein subfamilies by small molecules is of great value to explore the contribution of G protein signaling in physiology and disease. It also represents a new opportunity to treat diseases, such ... -
Novel lantibiotics from microbial genomes
Dischinger, Jasmin (2012-07-19)The discovery of antibiotics was one of the most important milestones in medicine and in the fight against infectious disease. Today, more than 80% of anti-infective drugs are natural or semi-synthetic compounds. Rapidly ... -
Novel lipoate-binding proteins and their role in sulfur oxidation
Tanabe, Tomohisa Sebastian (2024-04-29)The global sulfur cycle is a highly complex network of interconnected processes that involve the conversion of organic and inorganic sulfur compounds across multiple redox states. Driven by prokaryotes through the oxidation, ... -
Novel magnetic nanoparticles: Size and surfactant effects on geometric and electronic structure, probed using X-ray Absorption Spectroscopy
Palina, Natalie (2005)The investigation of magnetic nanoparticles is of great interest for potential applications. Due to huge surface, the properties of nanoparticles deviate from those of bulk material. In order to understand and control these ... -
Novel Methods for Chiral Molecules in the Gas Phase and Neoteric Solvents
Blasius, Jan (2024-03-19)This thesis focuses on the development and application of computational methods for the calculation of infrared (IR) and vibrational circular dichroism (VCD) spectra in the gas and liquid phase, with special emphasis on ... -
Novel Methods for Molecular and Ionic Liquids: From Fundamentals to Applications as Electrolytes
Ingenmey, Johannes Carl Maria (2021-09-13)The trend towards sustainable technologies and processes requires the development of suitable solvents and electrolytes. In this regard, next to traditional molecular solvents, ionic liquids (ILs) are regarded as promising ... -
Novel Molecular Si(II) Precursors for Synthesis of the First Compounds with Metal-Silicon Triple Bonds
Chernov, Oleg (2012-09-27)NHC-adducts of reactive silylenes were isolated as crystalline thermally stable solids. The NHC-adducts of SiBr<sub>2</sub> and SiI<sub>2</sub> were prepared upon reduction of the corresponding NHC adducts of silicon ... -
Novel Nicotinic Acetylcholine Receptor Ligands based on Cytisine and Choline: Synthesis, In vitro Evaluation and Structure-Activity Relationships
Munoz, Lenka (2005)It has been long accepted that targeting nAChRs represent a pathway for the treatment of various CNS-related and non CNS-related disorders (e.g. Alzheimer's and Parkinson's disease, schizophrenia, depression, inflammation, ... -
Novel Nicotinic Acetylcholine Receptor Ligands based on Cytisine, Ferruginine, Anatoxin-a and Choline: In vitro Evaluation and Structure-Activity Relationships
Tilotta, Maria Cristina (2004)Nicotinic acetylcholine receptors (nAChRs), excitatory ligand-gated cation channels, are transmembranic allosteric proteins composed of five polypeptide chains. The subtype at the neuromuscular junction consists of α1, β1, ... -
Novel Search Techniques to Detect Pulsar Black Hole Binaries in Radio Observations
Balakrishnan, Vishnu (2022-02-21)Pulsars are rapidly rotating highly magnetised neutron stars that emit beams of electromagnetic radiation from their magnetic poles. These compact objects are unique as they are one of the densest forms of matter known in ... -
Novel Secondary Metabolites from Endophytic Marine-derived Fungi
Almeida, Celso (2011-02-22)The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. Marine microorganisms, such as fungi often occur associated with macroorganisms like algae, ... -
Novel Small Molecule Inhibitors Dissecting GEF-dependent and -independent Cytohesin Functions in Immune Cell Signaling
Novak, Nina Maria (2014-06-20)Cytohesins are guanine nucleotide exchange factors (GEFs) for the small GTPases of the ARF family. They play important roles in immune cell signaling, immune cell adhesion and migration and furthermore in non-immune insulin ... -
Novel vaccination strategies for CD4+ T cell immunotherapy of melanoma
Shridhar, Naveen (2019-09-06)Immunotherapy has emerged as a standard treatment modality in melanoma and many other cancers. While a lot is known about the anti-tumoral effector functions of CD8+ T cells, CD4+ T cells remain less well understood in ... -
NRF2 mediated oxidative stress response activity during early in vitro bovine embryo development
Amin, Ahmed Abdelsamad Zaki (2015-03-30)Overcoming oxidative stress is one of the various embryo challenges to survive under suboptimal conditions during in vitro production of bovine embryos. Thus, the present study aimed to examine the ability of preimplantation ... -
Nuclear export of single native mRNA molecules observed via light sheet fluorescence microscopy and transcriptional regulation of BR2.1 during heat-shock
Kaminski, Tim Patrick (2015-01-06)Eucaryotes store most of their genetic information in the nucleus. Parts of this information encode the amino acid sequence of proteins. To synthesize a protein according to the nucleotide sequence, first the corresponding ... -
Nuclear Lattice Investigations of Fundamental Symmetries
Körber, Christopher (2018-04-10)Fundamental symmetries (and their violations) play a significant role in active experimental searches of Beyond the Standard Model (BSM) signatures. An example of such phenomena is the neutron Electric Dipole Moment (EDM), ... -
Nuclear Physics in a finite volume: Investigation of two-particle and α-cluster systems
Stellin, Gianluca (2021-01-25)We investigate both analytically and numerically some artifacts introduced by the lattice environment in two-body charged fermion and antifermion systems and in α-conjugate nuclei. The finite (hyper)cubic lattice as a ... -
Nuclear Structure of Light Ca and Heavy Cr Isotopes
Bürger, Alexander (2007)Although the nuclear shell model was conceived almost 60 years ago, and despite the continuous efforts in experimental and theoretical nuclear physics research, the prediction of nuclear properties is still a challenging ...