Fakultäten der Universität Bonn: Suche
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Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Model-based formulation of amorphous solid dispersions made by hot-melt extrusion
(2019-08-21)
Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of ......
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Sphärische Lyophilisate zur pulmonalen Proteinapplikation
(2019-07-12)
Die pharmazeutische Sprüht-Gefrier-Trocknung (Spray-Freeze-Drying) umfasst ein heterogenes Feld von Technologien mit primären Anwendungen in den Bereichen Löslichkeitsverbesserung, pulmonale und nadelfreie intra-dermale ...
Development and Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Population Model for Elderly Individuals
(2019-07-04)
Clinical drug development is traditionally focused on young and middle-aged adults. The elderly are often underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug ...
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
(2019-04-30)
Multiple Sclerosis (MS) is one of the most prevalent neurodegenerative diseases for which a cure is not yet available. MS is a complex disease for numerous reasons; its etiology is unknown, the diagnosis is not exclusive, ...
Analyzing feedbacks in a forest soil-vegetation-atmosphere system
(2019-05-03)
In this study, the soil-vegetation-atmosphere system of a 38 ha forested headwater catchment in the Eifel region (western Germany) was analyzed with the aim to improve the understanding of the impacts of climate forcings ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
In dieser Arbeit wurden verschiedene Rückkopplungen im Boden-Pflanze-Atmosphärensystem eines 38 ha großen bewaldeten Einzugsgebietes in der Eifel (Westdeutschland) analysiert. Ziel war, das Verständnis der Auswirkungen von ......
Analysis of Multitarget Activities and Assay Interference Characteristics of Pharmaceutically Relevant Compounds
(2019-05-29)
The availability of large amounts of data in public repositories provide a useful source of knowledge in the field of drug discovery. Given the increasing sizes of compound databases and volumes of activity data, computational ...
A water storage reanalysis over the European continent: assimilation of GRACE data into a high-resolution hydrological model and validation
(2019-04-18)
Continental water storage and redistribution within the Earth’s system are key variables of the terrestrial water cycle. Changes in water storage and fluxes may affect resources for drinking water and irrigation, lead ...
African nightshade and African spinach: A neglected and underutilized resource with significant potential to manage plant-parasitic nematodes
(2019-05-07)
African indigenous vegetables (AIV) are essential for dietary diversification and ensuring nutritional requirements for people in sub-Sahara Africa. AIV have been largely marginalized by agriculture research, yet they are ......
In Afrika heimische Blattgemüse (AIV) sind essentielle Komponenten einer reichhaltigen und ausreichenden Ernährung der Einwohner sub-Sahara Afrikas. Obwohl AIV ausdauernd und tolerant gegen wechselnde Umweltbedingungen ......
In Afrika heimische Blattgemüse (AIV) sind essentielle Komponenten einer reichhaltigen und ausreichenden Ernährung der Einwohner sub-Sahara Afrikas. Obwohl AIV ausdauernd und tolerant gegen wechselnde Umweltbedingungen ......