Faculties of University Bonn: Search
Now showing items 11-20 of 51
The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)
Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ......
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)
Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies into measuring the Higgs CP-state in H → ττ decays at ATLAS
(2020-07-16)
Since the discovery of the Higgs boson in 2012, experimental particle physics made large efforts to measure all properties of the new particle to characterise all its properties as precisely as possible.
So far, all ...
So far, all ...
Totalsynthesen neuartiger Leupylogs: vereinfachte Strukturanaloga der Leupyrrine
(2020-06-03)
Die vorliegende Dissertation behandelt die totalsynthetische Darstellung von neuartigen Strukturanaloga der Leupyrrine. Diese Stoffklasse myxobakterieller Sekundärmetabolite zeichnet sich durch die Kombination einzigartiger ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Population pharmacokinetic modeling to understand antineoplastic treatment
(2020-06-29)
Introduction: The pronounced variability in pharmacokinetics of antineoplastic drugs caused by known and unknown sources translates into variability in therapeutic outcome. This is a major concern for these ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Transient Heme-Protein Interactions: Structural and Functional Studies on Interleukin-36α and Amyloid-β
(2020-08-25)
The porphyrin heme is primarily known as a pivotal blood component. As functional part of hemoglobin, heme is responsible for the blood’s vibrant red color and enables the transport of oxygen within the body. Moreover, ......
Das Porphyrin Häm ist vor allem als zentrale Komponente des Bluts bekannt. Als funktioneller Bestandteil des Hämoglobins verleiht es dem Blut seine leuchtend rote Farbe und ermöglicht den Transport von Sauerstoff innerhalb ......
Das Porphyrin Häm ist vor allem als zentrale Komponente des Bluts bekannt. Als funktioneller Bestandteil des Hämoglobins verleiht es dem Blut seine leuchtend rote Farbe und ermöglicht den Transport von Sauerstoff innerhalb ......
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...