Fakultäten der Universität Bonn: Suche
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Microevolutionary processes and taxonomic investigations of the Atacama Desert flora
(2020-12-22)
Plant evolutionary processes in the hyper arid Atacama Desert of northern Chile are here investigated using our species/species complexes as case studies based on the following research questions:
(1) Are populations ......
(1) Are populations ......
Development of workflows for metabarcoding of mass-samples: A case study on Diptera
(2020-02-14)
The main goal was developing a workflow for comprehensive biodiversity monitoring using a DNA Barcoding approach. As one of the major insect groups in the Palearctic the diverse order of Diptera served as an experimental ...
Development of oligomer-specific antibodies against tau protein and testing of therapeutic potential in a cell model of tau pathology
(2020-04-15)
Tau, a microtubule associated protein, forms abnormal aggregates in many neurodegenerative diseases such as Alzheimer disease (AD). There is an urgent need for disease-modifying therapies of AD and related tauopathies. ......
Regulation des Cochaperons BAG3 durch Phosphorylierung und Dephosphorylierung
(2020-01-07)
Die Zelle ist die kleinste Organisationseinheit, aus der alle Organismen aufgebaut sind. Sie ist auf ein Gleichgewicht der Proteinausstattung, die Proteostase, angewiesen. Auch das Cytoskelett ist essentiell für die Zelle, ...
In vitro and in vivo assessment of lead toxicity on mammalian female reproduction and effect of antioxidants
(2020-03-17)
Heavy metals are among the environmental toxicants incurring great concern for human and animals because of their toxicity even at low concentrations. Lead (Pb) has been shown to induce severe and long lasting effects on ......
Changes of inner teat morphology caused by the milking process and by incomplete milking during dry-off as assessed by innovative technologies
(2020-03-03)
In dairy farming, the timing of the lactation cycle and the way of milk removal differ considerably from the natural conditions. Ensuring good health and wellbeing of farm animals is of great interest from both an economic ...
Analysis of two selected cell wall proteins and one lncRNA involved in desiccation tolerance of the resurrection plant Craterostigma plantagineum
(2020-01-07)
Water deficit is a severe stress negatively affecting plant growth and productivity. Extreme dehydration, termed desiccation, will lead to substantial water loss from cells and eventually results in less than 10% RWC ...
Chemoinformatics-Driven Approaches for Kinase Drug Discovery
(2020-01-07)
Given their importance for the majority of cell physiology processes, protein kinases are among the most extensively studied protein targets in drug discovery. Inappropriate regulation of their basal levels results in ...
Unraveling TRIM71-mediated RNA regulatory mechanisms during developmental and oncogenic processes
(2020-05-18)
A dysregulation in the tight control of cell proliferation and differentiation severely affects developmental processes, and can lead to oncogenic transformation in the adult organism. The stem cell-specific protein TRIM71 ...
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
(2020-08-10)
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to ...