Faculties of University Bonn: Search
Now showing items 71-80 of 92
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......
The enzyme HPGD is critical for regulatory T cell function in adipose tissue
(2020-02-06)
Regulatory T cells (Treg cells) are essential for maintaining immune homeostasis. However, how Treg cells exert their function in tissue specific environments is often unknown. We have found ......
MAIT cell diversity, function and impact on dendritic cells
(2020-04-01)
T cells represent an important component of the immune system. Whilst early studies were largely focused on the role of conventional CD8+ and CD4+ T cells that recognize peptide-antigens in association ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Application of BioID to in vitro organelle and in vivo cell-type-specific proteomics
(2020-09-17)
A genetically modified biotin ligase BirA (Arg118Gly), termed BioID (BirA*), can be induced to add a reactive form of biotin to proximate proteins in the cytosol and nucleus. The biotinylated proteins can be purified and ......
Untersuchungen zur heterologen Biosynthese des seltenen kompatiblen Soluts Nε-Acetyl-β-Lysin
(2020-08-28)
Das Aminosäurederivat Nε-Acetyl-β-Lysin (NAβL) wird von methanogenen Archaeen und einigen Vertretern der Bakterien zur Anpassung an osmotischen Stress produziert. Bisher wurden vor allem die zur Produktion ......
Studies on the heterologous biosynthesis of the rare compatible solute Nε-acetyl-β-lysine
The amino acid derivative Nε-acetyl-β-lysine (NAβL) is produced by methanogenic ......
Studies on the heterologous biosynthesis of the rare compatible solute Nε-acetyl-β-lysine
The amino acid derivative Nε-acetyl-β-lysine (NAβL) is produced by methanogenic ......
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Historical Biogeography and Macroevolution of the Atacama Desert Flora
(2020-09-17)
Located in northern Chile, the Atacama Desert is not only one of the oldest deserts but also one of the driest places on earth with hyperarid conditions prevailing since the Miocene or earlier. Despite the extreme conditions ...
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......