Fakultäten der Universität Bonn: Suche
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Metal-Air Batteries: Metal Deposition and Alloying in Aprotic Electrolytes for Anode Materials: Kinetic Behaviour
(2022-01-03)
Metal air batteries concerning the increase in storage capacity, increase the lifetime, and reduction of weight, size and costs leads to more and more interest in battery research. The alloying-type anodes (Sb, Sn, and Bi ...
Radiometalle in der nuklearmedizinischen Anwendung: Prozessentwicklung und Translation in die klinische Routineanwendung
(2022-04-20)
In der vorliegenden Arbeit wurden mehrere Aspekte der täglichen radiopharmazeuti-schen Arbeit in der Nuklearmedizin bearbeitet. Der Fokus lag dabei auf der Translation von neuen Tracern aus der Forschung in die klinische ...
Mass Spectrometric Profiling of Lysosomal Protein Interactions, Structures, and Half-lives via Cross-Linking and Pulse Stable Isotope Labeling
(2022-07-08)
In mammalian cells, the lysosome is the central organelle for the degradation of macromolecules and recycling of their building blocks. Mutations in almost every known lysosomal hydrolase lead to a group of rare but ...
Computation of Mass Spectra Using Quantum Chemical Methods
(2022-11-23)
Mass spectrometry (MS) is widely used for the structural elucidation of compounds in a vast variety of scientific research. Unfortunately, many methods that aim to predict mass spectra cannot often elucidate the complete ...
From Density Functional Theory to Tight Binding: Development of Robust and Efficient Quantum Chemistry Methods
(2022-12-07)
The main topics of this thesis are efficient quantum chemical methods, their development, and the verification using existing and newly devised benchmark sets. The spectrum of quantum chemical methods discussed here includes ...
On the importance of meteorological parameters in processes affecting the chemical composition of the tropsphere
(2022-12-22)
Investigating the interaction of meteorology and chemistry in the troposphere is important for the identification of the processes which drive the evolution of tropospheric composition in a changing climate. It does not ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Selbstassemblierte Monolagen organischer Moleküle auf Festkörperoberflächen
(2022-08-22)
Im Rahmen der vorliegenden Arbeit wurden selbstassemblierte Monolagen organischer Moleküle an der Fest-Flüssig-Grenzfläche von Graphit mittels Rastertunnelmikroskopie untersucht. Die Arbeit verfolgte das Ziel, das Verständnis ......
Design, synthesis and optimization of receptor ligands: tools for studying purine-activated and related orphan G protein-coupled receptors
(2022-04-01)
Adenosine receptors
The A2A and A2B adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ...
The A2A and A2B adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ...