Faculties of University Bonn: Search
Now showing items 11-20 of 22
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
In situ observations of reaction and transport phenomena during silicate glass corrosion by fluid-cell Raman spectroscopy: Method development and applications
(2020-07-06)
Borosilicate glass is the preferred material for the immobilization of high-level nuclear waste and an important material for various industries. Silicate glasses, however, are prone to corrosion by aqueous solutions, which ......
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Diastereoselektive Titanocen(III)-Katalyse – Synthese benzylischer 1,3-Dioxolane und 1,3-Oxazolidine
(2023-09-14)
(noch nicht zugänglich / not yet accessible)
On the importance of meteorological parameters in processes affecting the chemical composition of the tropsphere
(2022-12-22)
Investigating the interaction of meteorology and chemistry in the troposphere is important for the identification of the processes which drive the evolution of tropospheric composition in a changing climate. It does not ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Die humane RNA-Helikase DDX19: Identifizierung ihres Kernimportsignals und Analyse ihrer Rolle beim Export von mRNA
(2023-01-20)
Der mRNP-Export durch DDX19
Der nukleare Export von mRNPs (messenger-Ribonukleoproteine) wird in menschlichen Zellen durch die RNA-Helikase DDX19, zusammen mit dem Nukleoporin NUP214 und dem Exportfaktor Gle1 ......
The human RNA helicase DDX19 : identification of its nuclear import signal and analysis of its role in mRNA export
The mRNP export by DDX19
Nuclear export of mRNPs (messenger ribonucleoproteins) ......
Der nukleare Export von mRNPs (messenger-Ribonukleoproteine) wird in menschlichen Zellen durch die RNA-Helikase DDX19, zusammen mit dem Nukleoporin NUP214 und dem Exportfaktor Gle1 ......
The human RNA helicase DDX19 : identification of its nuclear import signal and analysis of its role in mRNA export
The mRNP export by DDX19
Nuclear export of mRNPs (messenger ribonucleoproteins) ......
Biosynthesis and Analysis of 3-Isobutyl-2-methoxypyrazine in Capsicum annuum (Bell Pepper) Plants
(2023-06-21)
3-Alkyl-2-methoxypyrazines (MPs) are highly odorous compounds occurring in a wide range of raw vegetables. Due to their high odor activity, they have been of great research interest. The most prominent MPs are 3-isopropy ...