Faculties of University Bonn: Search
Now showing items 31-40 of 84
GPR183 Expression on Pulmonary Conventional Dendritic Cell Type 2 Dictates Subtissular Localisation and Instructs Their Survival via the Thymic Stromal Lymphopoietin (TSLP) – TSLP Receptor (TSLPR) Axis
(2021-07-06)
Introduction: G protein-coupled receptor 183 (GPR183) is a chemotactic receptor, highly expressed by immune cells. Upon activation by its ligand, 7a,25-dihydroxycholesterol (7a,25-OHC), GPR183 activates downstream signals ......
Analyse der intranukleären Dynamik und des Exports der ribosomalen 60S-Untereinheit
(2021-09-13)
Die Proteinbiosynthese wird von Ribosomen - großen molekularen Maschinen - durchgeführt, die aus zahlreichen verschiedenen Proteinen und einem ribosomalen RNA-Rückgrat bestehen. Die Biogenese der ribosomalen Untereinheiten ...
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)
Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ...
Advanced migration assays for studying chemotaxis of slow moving cells
(2021-12-16)
Chemotaxis of slow moving cells plays a crucial role in numerous physiological and pathophysiological processes; including tumour metastasis, development, and wound healing. Therefore, a comprehensive understanding of ...
Exploration of bioresources enables detection and characterization of natural products with antibacterial activities and elucidation of the corresponding biosyntheses for derivative generation
(2021-11-17)
The discovery of antibiotics in the early 20th century sparked a medicinal revolution, which for the first time in history enabled humankind to effectively combat bacterial infections. Despite this immense success, the ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...
Evolution of DNA methylation in insects
(2021-05-21)
DNA methylation, the addition of a methyl group (-CH3) to a genomic cytosine by a DNA methyltransferase, is the most thoroughly studied epigenetic modification across eukaryotes. Functionally, it is associated with the ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Die biologische Funktion der N1-2´O-Methylierung eukaryotischer mRNA durch die Methyltransferase CMTr1
(2021-05-14)
Eukaryoten modifizieren das 5´-Ende ihrer mRNA mit einem invertierten N7-methyliertem Guanosin (m7G). Diese Cap0 genannte Struktur wird in höheren Eukaryoten durch die Methyltransferase CMTr1 weiter modifiziert: CMTr1 ...
Entwicklung eines in vitro Testsystems zur Identifizierung pflanzlicher Signale für Mehltau (Blumeria graminis) an Weizen (Triticum aestivum)
(2021-02-11)
Blumeria graminis ist der Erreger des Echten Mehltaus an Weizen (Triticum aestivum), einer der wichtigsten Kulturpflanzen weltweit. Durch diese Pflanzenkrankheit können hohe Ernteverluste verursacht werden. Die Keimung und ......
Development of an in vitro test system to identify plant signals for powdery mildew (Blumeria graminis) on wheat (Triticum aestivum
Blumeria graminis is the causal agent of powdery mildew on wheat ......
Development of an in vitro test system to identify plant signals for powdery mildew (Blumeria graminis) on wheat (Triticum aestivum
Blumeria graminis is the causal agent of powdery mildew on wheat ......