Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 21-30 von 93
Different functions played by centrosomal protein CEP135 and centriolar satellite proteins SSX2IP and WDR8
(2022-04-05)
The centrosome of animal cells is a crucial organelle that regulates cell division, cell migration, ciliogenesis, intracellular transportation and polar determination with microtubule organizing center as its primary ...
Compartmentalisation of cAMP in Brown Adipocytes
(2022-02-14)
The second messenger, 3',5'-cyclic adenosine monophosphate (cAMP) plays an important role in governing the function and differentiation of brown adipocytes. Upon the stimulation of Gs-coupled G protein-coupled ...
Investigations on Marine Natural Products from Indo-Pacific Nudibranchia (Mollusca: Gastropoda): Chemoecology, Medicinal Potential & Toxin Resistance
(2022-03-22)
This thesis focusses on the investigation of marine natural products (MNPs) from nudibranchs of the Central Indo-Pacific Ocean and their food sources. MNPs are important lead structures in the drug discovery process, as ......
Vorkommen Antibiotika-resistenter Bakterien in der aquatischen Umwelt: Zusammenhänge zu dem Vorkommen antibiotisch wirkender Substanzen
(2022-01-05)
Ein Anstieg der Resistenzen bei gleichzeitiger Stagnation hinsichtlich der Ent-wicklung neuer Antibiotika ist vor allem für Infektionen mit Gram-negativen Bakte-rien kritisch. Die WHO spezifizierte bereits 2014 ...
Investigation of novel pathways causing autoinflammatory disease
(2022-05-17)
Autoinflammatory diseases (AIDs) are rare pathologies caused by mutations in genes associated with innate immune pathways. Investigating the underlying molecular defects contributes to identification of targeted treatment ......
Global 3’-UTR Length Changes Form a Novel Layer of Regulation in the Macrophage Response to Interferon-Beta
(2022-05-20)
Interferon signaling is one of the most important mechanisms shaping innate immune responses and needs to be tightly regulated to successfully fight infections and modulate immune responses while avoiding toxicity.
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
(2022-05-23)
Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ...
Polare und schalenförmige molekulare Speichenräder
(2022-05-16)
Ziel dieser Arbeit war zum einen die Synthese eines polaren amphiphilen Phenylen-basierten molekularen Speichenrades (MSWs) mit geringerer Symmetrie. Die Amphiphilie soll durch die Einführung von Pyridylgruppen erreicht ...
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are among the first line of host defense against
invading pathogens. They are equipped with pattern recognition receptors (PRRs) that
detect conserved components of microbes and in ...
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)
Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...