Faculties of University Bonn: Search
Now showing items 1101-1110 of 1345
Genome mining of marine bacteria for bioactive metabolites
(2019-02-04)
Marine bacteria have come into the focus for natural product discovery as a consequence of the emergence of antibiotic resistance. This was additionally boosted by the limitations encountered in drug developments from ...
Characterization of regulatory T cells in atopic dermatitis
(2019-02-05)
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with increasing incidence. It has been suggested that Tregs play a role in the pathogenesis of AD, as Tregs regulate immune homeostasis ......
Establishment of a cell-based anti-prion compound screen and analysis of host response to prion infection in cerebellar organotypic slice cultures
(2019-02-19)
Prions are unconventional infectious agents that cause always fatal neurodegenerative diseases termed prion disease or transmissible spongiform encephalopathies in mammals. Prion diseases are caused by an accumulation of ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Effects of Mitochondrial Nucleases on mtDNA Degradation
(2019-01-11)
Mitochondria are unique to have a multicopy genome, resulting in a substantially different fate of damaged DNA molecules in comparison to nuclear DNA. Damaged DNA usually represents only a small fraction of total mitochondrial ...
Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments
(2019-01-18)
The cumulative doctoral thesis "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments" deals with the application of stable isotopes for structure elucidation ...
Bioinformatische und in-vitro-Analyse der frs-Biosynthesegencluster von Cand. Burkholderia crenata und Chromobacterium vaccinii
(2019-07-03)
FR900359 (FR) ist ein selektiver Gq-Proteininhibitor, der ursprünglich aus der Pflanze Ardisia crenata isoliert wurde. G-Proteine spielen eine zentrale Rolle in der Signalübertragung von G-Protein ......
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)
Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...