Faculties of University Bonn: Search
Now showing items 1201-1210 of 1327
Evolution and genetic basis of pelvic-brooding, a derived reproductive strategy in Sulawesi ricefishes (Beloniformes: Adrianichthyidae)
(2022-11-04)
In Sulawesi ricefishes (Adrianichthyidae, Beloniformes) a derived reproductive strategy evolved. It is unique in the way that females of pelvic brooding species carry the eggs for up to 18 days until the fry hatches outside ......
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer’s disease mouse model
(2021-03-18)
One of the most prominent hallmarks of Alzheimer’s Disease (AD) is the accumulation of amyloid beta (Abeta) species, which have the tendency to form extracellular insoluble Abeta plaques and induce reactive astrogliosis ...
Regulation of inflammasome activation: roles for phospholipase C and mitochondria
(2021-08-05)
Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ......
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
I) Characterization of LytR-CpsA-Psr enzymes and their role in Staphylococcus aureus cell wall formation
II) Elucidating the mode of action of Cacaoidin, a novel class V lantibiotic
(2022-04-04)
Antibiotic resistance poses a serious threat to human health, demanding for the discovery and development of antibiotics with resistance-breaking properties. New antibiotics should be sought with the focus on novel chemistry ...
Carvedilol-mediated signal transduction at the β2 adrenergic receptor
(2022-07-14)
G protein-coupled receptors (GPCRs) comprise the most prominent family of membrane proteins in the mammalian genome. They are required to relay extracellular cues into a cellular response. The environmental interactions ...
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Contribution of resident macrophages to the fetal liver hematopoietic stem cell niche
(2022-07-29)
Tissue-resident macrophages are a heterogeneous population of phagocytes found in almost all tissues of the body. Recent studies indicate that most resident macrophages originate from yolk sac progenitors and are maintained ...
Keeping in Touch: Visualising and Perturbing Photorespiratory Organelle Proximity in Plants
(2023-12-06)
Organelles within cells are typically depicted as isolated structures, but increasing evidence shows that they are interconnected via specific membrane contact sites (MCS). While MCS research in mammals and yeast is gaining ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...