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Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Vergleich der „Train of four“: Messungen des M. adductor pollicis und des M. corrugator supercilii in Bezug auf die Wiederherstellung der pulmonalen Funktion nach neuromuskulärer Blockade
(2022-07-19)
Die Wiederherstellung der Lungenfunktion nach NMB erweist sich als ein Schlüsselfaktor zu Vermeidung einer PPC. Interessanterweise haben bisher allerdings nur wenige Studien Daten zum pulmonalen Funktionsstatus unmittelbar ...
A light-dependent aptamer-photoreceptor system enables spatiotemporal control of RNA biochemistry
(2022-07-29)
Light plays an important role in all kingdoms of life and regulates processes such as plant growth, flowering or vision in complex life forms. The growing field of optogenetics harnesses those properties by combining them ...
Effects on temporomandibular joint caused by orthodontic intermaxillary elastics: a finite element study
(2022-11-10)
The Finite element method was used to investigate whether variations of intermaxillary elastics would develop harmful effects on the healthy temporomandibular joint. The biomechanical behaviour of computed dynamic mouth ...
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
(2022-12-21)
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and ...
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
(2022-11-15)
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 ...
Endocannabinoid system and the aging locus coeruleus
(2022-11-28)
The locus coeruleus (LC) is a small nucleus located in the pons of the brainstem, representing the major source of noradrenaline (NE) in the central nervous system. Although the LC consists of a relatively low number of ...
COVID-19 and changes in global agri-food trade
(2022-04-09)
COVID-19 has raised questions about the resilience of agri-food trade to global shocks to the system. This paper analyses the changes in agri-food trade (values, extensive and intensive margin, and diversification) during ...