Faculties of University Bonn: Search
Now showing items 11-20 of 28
Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation
(2020-06-08)
The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ...
Compartmentalisation of cAMP in Brown Adipocytes
(2022-02-14)
The second messenger, 3',5'-cyclic adenosine monophosphate (cAMP) plays an important role in governing the function and differentiation of brown adipocytes. Upon the stimulation of Gs-coupled G protein-coupled ...
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Nucleic acid sensing in CD4 T cells during HIV-1 and other viral infections
(2021-10-15)
Viruses are small intracellular parasites and use the host cell’s biosynthesis machinery to replicate and spread. Therefore, viral particles incorporate structures that are similar to the ones that naturally occur within ...
Application of population, physiologically based, and semi-physiological pharmacokinetic modeling to assess sources of pharmacokinetic variability in individual drugs
(2020-06-05)
Large inter- and intra-individual variability in the response of drugs causes difficulties for clinicians to choose appropriate dosing regimens to target their therapeutic range. While underexposure might cause sub-therapeutic ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Activation of the innate immune system by endoplasmic reticulum stress and proteasome inhibition
(2023-08-24)
The impact of proteotoxic stress on innate immune activation is currently unclear. Here, I investigated differential effects of ER stress and proteasome inhibition using genetically modified cell lines and primary human ...