Fakultäten der Universität Bonn: Suche
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Entwicklung und Bewertung verschiedener Methoden zur Aktivitätsbestimmung von Ectonucleotidasen und zur Identifizierung von Inhibitoren
(2015-05-27)
Ectonucleotidasen werden ubiquitär im Körper exprimiert und sind an vielen (patho)physiologischen Prozessen beteiligt. Sie sind daher als potentielle Arzneistofftargets von großem Interesse (z. B. in der ...
Data-Driven Analysis and Interpolation of Optical Material Properties
(2015-05-11)
Reproducing the characteristic appearance of materials digitally is of considerable importance for the creation of photo-realistic images. However, due to the high complexity of many real-world materials, modeling them ...
Characterization of panglial gap junction networks in the thalamus and hippocampus reveals glial heterogeneity
(2015-05-27)
Increasing evidence over the past decades revealed the importance of glia in the brain. In this study, astrocytes in the ventrobasal thalamus were characterized in detail for the first time. Glial heterogeneity was ...
The cannabinoid receptor 2: from mouse to human
(2015-05-13)
The endocannabinoid system (ECS) regulates numerous cellular and physiological processes. Nowadays, the system comprises two G protein-coupled receptors named CB1 and CB2 receptor, and the endogenous ligands anandamide ......
Geostatistical Analysis of Genetic Diversity in the Present Male Argentine Population
(2015-08-03)
The geographical study of genetic diversity has a long history in fields related to population genetics. Its relevance has been already acknowledged in the 1940's and numerous tools have been developed since then. Most of ...
Statistical Analyses of Massive Stars and Stellar Populations
(2015-03-04)
Massive stars, i.e. stars more massive than about ten times that of the Sun, are key agents in the Universe. They synthesise many of the chemical elements that are so important for life on Earth, helped reionising the early ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
An Analysis and Evaluation of the Development of the QRD Human Product Information Template used in Package Leaflets
(2015-03-13)
Package leaflets of medicines distributed within the European Union must reflect the QRD template. Since the first edition of the QRD template from 1996, thirteen revisions have followed. During development the QRD template ...
Progressive orogenic deformation and metamorphism along the Combin Fault and Dent Blanche Basal Thrust in the Swiss-Italian Western Alps
(2015-03-24)
In the Western Alps of Switzerland and Italy, a stack of oceanic and continental units assembled during Late Cretaceous – Paleogene Alpine subduction, exhumation, and accretion. In the study area in the southern Valais and ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......